All AbMole products are for research use only, cannot be used for human consumption.
Interleukin-33 (IL-33) is a pro-inflammatory cytokine in the IL-1 family. Il-33 is expressed in a variety of cells, including epithelial and endothelial cells, smooth muscle cells, macrophages, and fibroblasts. The main receptors of IL-33 are ST2 and IL-1 receptor accessory protein (IL-1RACP), both of which belong to the IL-1 receptor family. Il-33 locates in the nucleus of resting cells, where it binds the chromatin of the H2A-H2B histone complex as a transcription inhibitor. Il-33 is secreted by cells during injury and induces t-helper cell type 2 inflammatory response. There is evidence that IL-33 plays a role in autoimmune diseases.
Purity: > 98%
Endotoxin: protein < 1 EU/μg
Theoretical molecular weight: 17.5 kDa
Lyophilized from a 0.2 μm filtered solution in PBS, 1 mM EDTA.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage | Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
[1] Giuseppe Ercolano, et al. Nat Commun. PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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