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Recombinant Human EpCAM/Trop1 (Expi293, His)

Cat. No. M15093
Recombinant Human EpCAM/Trop1 (Expi293, His) Structure
Synonym:

CD326 antigen; CD326; EGP; EGP-2

Size Price Availability Quantity
100ug USD 500  USD500 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin ≤ 1 EU/μg
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: Expi293
Purity: SDS-PAGE analysis > 95%, HPLC analysis > 95%
Endotoxin: LAL method for determination of protein ≤1 EU/μg
Apparent molecular weight: 30 ~ 45 kDa, reduced under SDS-PAGE
Storage and stability: After receiving, the product remains stable at -70°C or -20°C for up to 6 months. Avoid repeated freeze-thaw cycles


Bioactivity: 0.2 μg/ mL (100 μ L /Well) immobilized human EpCAM. The dose-response curve of anti-Trop1 antibody EC50 was 8.7 ng/ mL by ELISA. Epithelial cell adhesion molecule (EpCAM), also known as KS1/4, GP40, GA733-2, 17-1A, and TROP-1, is a 40 kDa transmembrane glycoprotein, It consists of an extracellular domain of 242 amino acids (AA) (with two EGF-like repeats), a 23 AA transmembrane segment, and a 26 AA cytoplasmic domain.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin ≤ 1 EU/μg
Solubility It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage at -20°C
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Keywords: Recombinant Human EpCAM/Trop1 (Expi293, His), CD326 antigen; CD326; EGP; EGP-2 supplier, Cytokines, inhibitors

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