Expression system: Expi293
Purity: SDS-PAGE analysis > 95%, HPLC analysis > 95%
Endotoxin: LAL method for determination of protein ≤1 EU/μg
Apparent molecular weight: 30 ~ 45 kDa, reduced under SDS-PAGE
Storage and stability: After receiving, the product remains stable at -70°C or -20°C for up to 6 months. Avoid repeated freeze-thaw cycles
Bioactivity: 0.2 μg/ mL (100 μ L /Well) immobilized human EpCAM. The dose-response curve of anti-Trop1 antibody EC50 was 8.7 ng/ mL by ELISA. Epithelial cell adhesion molecule (EpCAM), also known as KS1/4, GP40, GA733-2, 17-1A, and TROP-1, is a 40 kDa transmembrane glycoprotein, It consists of an extracellular domain of 242 amino acids (AA) (with two EGF-like repeats), a 23 AA transmembrane segment, and a 26 AA cytoplasmic domain.
|Solubility (25°C)||It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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