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Interleukin-1 alpha (IL-1α) is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 2.0 pg/ml, corresponding to a specific activity of > 5.0 × 108 IU/mg. IL-1α has a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells.
Recombinant Mouse IL-1α expressed the target gene encoding Ser115-Ser270.
Accession: # Q3U0Y6
Theoretical Molecular Weight: 17.9 kDa
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
[4] Kam Leung. 99mTc-Interleukin-18-binding protein-Fc-interlukin-1 receptor antagonist
[5] William P Arend. Cytokine Growth Factor Rev. The balance between IL-1 and IL-1Ra in disease
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Products are for research use only. Not for human use. We do not sell to patients.
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