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Lavendustin B

Cat. No. M20765

All AbMole products are for research use only, cannot be used for human consumption.

Lavendustin B Structure

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Biological Activity

Lavendustin B inhibits HIV-1 integrase (IN) interaction with its cognate cellular cofactor lens epithelium-derived growth factor (LEDGF/p75). Lavendustin B is an inhibitor of Tyrosine Kinase and also a competitive inhibitor of glucose transporter 1 (Glut1).

Chemical Information
Molecular Weight 365.38
Formula C21H19NO5
CAS Number 125697-91-8
Solubility (25°C) DMSO 73 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Fatima E Agharbaoui, et al. Eur J Med Chem. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

[2] D Glahn, et al. Dev Biol. Tyrosine kinase inhibitors block sperm-induced egg activation in Xenopus laevis

[3] M Hisatomi, et al. Jpn J Pharmacol. Modulation of tyrosine kinase activity has multiple actions on insulin release from the pancreatic beta-cell: studies with lavendustin A

[4] S Meizel, et al. J Androl. Chloride efflux during the progesterone-initiated human sperm acrosome reaction is inhibited by lavendustin A, a tyrosine kinase inhibitor

[5] D E Hu, et al. Br J Pharmacol. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A

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Keywords: Lavendustin B supplier, Integrase, inhibitors, activators

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