About 22 results found for searched term "Integrase" (0.143 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M30275 | HIV-1 integrase inhibitor | HIV Protease |
| HIV-1 integrase inhibitor is uesful for anti-HIV. | ||
| M1681 | BMS-707035 | Integrase |
| BMS707035 | ||
| BMS-707035 is an HIV-1 integrase (IN) inhibitor. HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic. | ||
| M1979 | Elvitegravir | Integrase |
| GS-9137, EVG | ||
| Elvitegravir (EVG) is a HIV integrase inhibitor with IC50 of 0.7 nM, 2.8 nM and 1.4 nM for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD, respectively. | ||
| M2595 | Raltegravir | Integrase |
| MK-0518 | ||
| Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectively. | ||
| M3195 | MK-2048 | Integrase |
| MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively. | ||
| M3484 | Dolutegravir | Integrase |
| GSK1349572 | ||
| Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. | ||
| M4752 | l-Chicoric-acid | HIV Protease |
| (-)-Chicoric acid; trans-Caffeoyltartaric acid | ||
| L-chicoric Acid ((-)-Chicoric Acid), a dicafoyl tartaric Acid, is a potent, selective and reversible INHIBITOR of HIV-1 integrase with an IC50 of approximately 100 nM. L-chicoric Acid also inhibits HIV-1 replication in tissue cultures. | ||
| M4824 | Dolutegravir sodium | Integrase |
| GSK-1349572A, DTG | ||
| Dolutegravir sodium is a potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity. | ||
| M5084 | Raltegravir potassium | Integrase |
| MK0518 potassium | ||
| Raltegravir potassium (MK0518 potassium) is a potent integrase (IN) inhibitor, used to treat HIV infection. | ||
| M9113 | Bictegravir | Integrase |
| GS-9883 | ||
| Bictegravir (GS-9883) is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM. | ||
| M9491 | BMS-538203 | HIV Protease |
| BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent. | ||
| M10371 | Cabotegravir | HIV Protease |
| S/GSK1265744; GSK744 | ||
| Cabotegravir, also known as S/GSK1265744 or GSK744, is potent HIV integrase inhibitor. | ||
| M20765 | Lavendustin B | Integrase |
| Lavendustin B inhibits HIV-1 integrase (IN) interaction with its cognate cellular cofactor lens epithelium-derived growth factor (LEDGF/p75). Lavendustin B is an inhibitor of Tyrosine Kinase and also a competitive inhibitor of glucose transporter 1 (Glut1). | ||
| M20886 | Bictegravir Sodium | Integrase |
| GS-9883 Sodium | ||
| Bictegravir (GS-9883) Sodium is a novel and potent inhibitor of HIV-1 integrase, specifically targets IN strand transfer activity with an IC50 of 7.5 nM. | ||
| M28373 | (±)-BI-D | HIV Protease |
| (±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site. IC50 value: 2.4–2.9 μM(HIV-Luc infection of WT and Hdgfrp2 KO cells) [1] Target: integrase inhibitor in vitro: Approximately 2.4–2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160–200 nM, in Psip1 and double-KO cells . | ||
| M28768 | BDM-2 | HIV Protease |
| BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN refers to integrase) (IC50=47 nM) with potent anti-Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC50 value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC50 value of 0.15 μM. BDM-2 exhibits highly selective and favorable cytotoxicity. | ||
| M29421 | Pirmitegravir | Others |
| STP0404 | ||
| Pirmitegravir is a potent and first-in-class inhibitor of allosteric integrase (ALLINI) that targets LEDGF/p75 binding site. Pirmitegravir displays picomolar IC50 in human PBMCs with a >24,000 therapeutic index against HIV-1. Pirmitegravir harbors outstanding anti-virus and safety properties. | ||
| M30181 | D77 | HIV Protease |
| D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells). IC50 value: 23.8 μg/ml (EC50, in MT-4 cell ), 5.03 μg/ml (EC50, in C8166 cell) Target: HIV-1 in vitro: D77 exhibits a highly specific binding affinity to HIV-1 integrase catalytic core domain.D77 induces a dramatic concentration-dependent decrease of α-galactosidase activity compared to the D77-untreated cells. D77 reveals a significant inhibition activity against the interaction of IN with IBD. | ||
| M30973 | (S)-BI-1001 | Others |
| (S)-BI-1001 (Compound 11) is an active S-enantiomer of BI-1001. (S)-BI-1001 exhibits antiviral potency against HIV-1 integrase with an IC50 of 28 nM, an EC50 of 450 nM and a Kd of 4.7 μM. | ||
| M30974 | LEDGIN6 | HIV Protease |
| CX05168; CX04328 | ||
| LEDGIN6 (CX05168) is a quinoline-based protein-protein interaction inhibitor of LEDGF/p75 and HIV integrase. | ||
| M39153 | Integracin B | Others |
| Integracin B is a potent dimeric alkyl aromatic inhibitor of HIV-1 integrase discovered from the screening of fungal extracts using an in vitro assay. Integracin B inhibits both coupled and strand transfer activity of HIV-1 integrase. | ||
| M41624 | Bis-T-23 | Dynamin |
| Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. | ||
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