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(±)-BI-D 

Cat. No. M28373

All AbMole products are for research use only, cannot be used for human consumption.

(±)-BI-D  Structure

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Quality Control & Documentation
Biological Activity

(±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site. IC50 value: 2.4–2.9 μM(HIV-Luc infection of WT and Hdgfrp2 KO cells) [1] Target: integrase inhibitor in vitro: Approximately 2.4–2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160–200 nM, in Psip1 and double-KO cells .

Chemical Information
Molecular Weight 405.49
Formula C25H27NO4
CAS Number 1416258-16-6
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Rui Li, et al. J Asian Nat Prod Res. Two new compounds from Verbena bonariensis

[2] Huiyuan Zhu, et al. Signal Transduct Target Ther. Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

[3] Takumi Yamaguchi, et al. Int J Chron Obstruct Pulmon Dis. Reliability and Validity of the Japanese Version of the Barthel Index Dyspnea Among Patients with Respiratory Diseases

[4] Lei Feng, et al. ACS Chem Biol. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

[5] S S Zinkel, et al. Oncogene. Rejuvenating Bi(d)ology

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Keywords: (±)-BI-D  supplier, HIV Protease, inhibitors, activators

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