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BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN refers to integrase) (IC50=47 nM) with potent anti-Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC50 value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC50 value of 0.15 μM. BDM-2 exhibits highly selective and favorable cytotoxicity.
| Molecular Weight | 394.5 |
| Formula | C25H30O4 |
| CAS Number | 1643876-33-8 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[2] Arthur Forer, et al. Protoplasma. Does 2,3-butanedione monoxime inhibit nonmuscle myosin?
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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