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BMS-707035

Cat. No. M1681
BMS-707035 Structure
Synonym:

BMS707035

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
2mg USD 49  USD49 In stock
5mg USD 78  USD78 In stock
10mg USD 130  USD130 In stock
50mg USD 420  USD420 In stock
100mg USD 650  USD650 In stock
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Quality Control
Biological Activity

BMS-707035 is an HIV-1 integrase (IN) inhibitor. HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 410.42
Formula C17H19FN4O5S
CAS Number 729607-74-3
Purity 99.85%
Solubility DMSO 36 mg/mL
Storage at -20°C
References

[1] Al-Mawsawi et al. Expert Opin Emerg Drugs. Anti-infectives: clinical progress of HIV-1 integrase inhibitors.

[2] Dayam et al. Drugs R D. HIV-1 integrase inhibitors: an emerging clinical reality.

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