Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor.
| Molecular Weight | 480.43 |
| Formula | C23H20N4O8 |
| CAS Number | 171674-76-3 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Dynamin Products |
|---|
| DynaMin inhibitory peptide, myristoylated
DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. |
| Dynamin inhibitory peptide
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. |
| DRP1i27 dihydrochloride
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). |
| Dynole 34-2
Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME). |
| Trimethyloctadecylammonium bromide
Trimethyloctadecylammonium bromide is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ. |
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