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Recombinant Human CXCL6 (Mammalian, C-6His)

Cat. No. M19986
Recombinant Human CXCL6 (Mammalian, C-6His) Structure

C-X-C Motif Chemokine 6; Chemokine Alpha 3

Size Price Availability Quantity
10ug USD 210  USD210 In stock
50ug USD 530  USD530 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: Mammalian
Apparent molecular weight: 13 KDa, reduction conditions
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Purity: > 95% as determined by reduced SDS-PAGE
Storage and Stability: lyophilized proteins should be stored at < -20°C, but can be stored for up to 3 weeks at room temperature. The recombinant protein solution can be stored at 4-7 ° C for 2-7 days. Aliquots of recombinant samples were stable at < -20°C for 3 months

Bioactivity: Chemokine (C-X-C-motif) ligand 6 (CXCL6) is a small cytokine in the CXC chemokine family. It is a potent neutrophil chemoattractant and activator, and it shares broad similarities with other CXC chemokines such as IL-8 and ENA-78. CXCL6 promoted the release of MMP-9 from granulocytes, indicating its potential role as an inflammatory mediator. It functionally uses the IL-8/CXCL8 receptor to chemotaxis neutrophils, but this is structurally related to the epithelal-derived neutrophil attractor 78 (ENA-78)/CXCL5. The human CXCL6 gene has been cloned and physically mapped to the CXC chemokine locus on chromosome 4. Mature human CXCL6 is a 75-amino acid (AA) protein with a predicted molecular weight of approximately 8 kDa. The homology of human CXCL6 to mouse and bovine CXCL6 was 60% and 67%, respectively.

Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Xiaolin Wang, et al. Cancer Biol Ther. CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation

[2] W Shen, et al. Eur Rev Med Pharmacol Sci. MicroRNA-101-5p inhibits the growth and metastasis of cervical cancer cell by inhibiting CXCL6

[3] Jia-Chi Ma, et al. World J Gastroenterol. Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer

[4] H Zhang, et al. Hum Reprod. The chemokine CXCL6 restricts human trophoblast cell migration and invasion by suppressing MMP-2 activity in the first trimester

[5] Helena M Linge, et al. Antimicrob Agents Chemother. The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial

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Keywords: Recombinant Human CXCL6 (Mammalian, C-6His), C-X-C Motif Chemokine 6; Chemokine Alpha 3 supplier, Cytokines, inhibitors, activators

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