Expression system: Mammalian
Apparent molecular weight: 13 KDa, reduction conditions
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Purity: > 95% as determined by reduced SDS-PAGE
Storage and Stability: lyophilized proteins should be stored at < -20°C, but can be stored for up to 3 weeks at room temperature. The recombinant protein solution can be stored at 4-7 ° C for 2-7 days. Aliquots of recombinant samples were stable at < -20°C for 3 months
Bioactivity: Chemokine (C-X-C-motif) ligand 6 (CXCL6) is a small cytokine in the CXC chemokine family. It is a potent neutrophil chemoattractant and activator, and it shares broad similarities with other CXC chemokines such as IL-8 and ENA-78. CXCL6 promoted the release of MMP-9 from granulocytes, indicating its potential role as an inflammatory mediator. It functionally uses the IL-8/CXCL8 receptor to chemotaxis neutrophils, but this is structurally related to the epithelal-derived neutrophil attractor 78 (ENA-78)/CXCL5. The human CXCL6 gene has been cloned and physically mapped to the CXC chemokine locus on chromosome 4. Mature human CXCL6 is a 75-amino acid (AA) protein with a predicted molecular weight of approximately 8 kDa. The homology of human CXCL6 to mouse and bovine CXCL6 was 60% and 67%, respectively.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Purity||>95% , Endotoxin < 1 EU/µg|
|Solubility||It is not recommended to reconstitute to a concentration less than 100μg/ml.|
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