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Recombinant Human CXCL6 (Mammalian, C-6His)

Cat. No. M19986
Recombinant Human CXCL6 (Mammalian, C-6His) Structure
Synonym:

C-X-C Motif Chemokine 6; Chemokine Alpha 3

Size Price Availability Quantity
10ug USD 168  USD210 In stock
50ug USD 424  USD530 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: Mammalian
Apparent molecular weight: 13 KDa, reduction conditions
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Purity: > 95% as determined by reduced SDS-PAGE
Storage and Stability: lyophilized proteins should be stored at < -20°C, but can be stored for up to 3 weeks at room temperature. The recombinant protein solution can be stored at 4-7 ° C for 2-7 days. Aliquots of recombinant samples were stable at < -20°C for 3 months


Bioactivity: Chemokine (C-X-C-motif) ligand 6 (CXCL6) is a small cytokine in the CXC chemokine family. It is a potent neutrophil chemoattractant and activator, and it shares broad similarities with other CXC chemokines such as IL-8 and ENA-78. CXCL6 promoted the release of MMP-9 from granulocytes, indicating its potential role as an inflammatory mediator. It functionally uses the IL-8/CXCL8 receptor to chemotaxis neutrophils, but this is structurally related to the epithelal-derived neutrophil attractor 78 (ENA-78)/CXCL5. The human CXCL6 gene has been cloned and physically mapped to the CXC chemokine locus on chromosome 4. Mature human CXCL6 is a 75-amino acid (AA) protein with a predicted molecular weight of approximately 8 kDa. The homology of human CXCL6 to mouse and bovine CXCL6 was 60% and 67%, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 1 EU/µg
Solubility It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage at -20°C
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Keywords: Recombinant Human CXCL6 (Mammalian, C-6His), C-X-C Motif Chemokine 6; Chemokine Alpha 3 supplier, Cytokines, inhibitors

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