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Recombinant Human CXCL6 (HEK293, C-6His)

Cat. No. M19986

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human CXCL6 (HEK293, C-6His) Structure
Synonym:

C-X-C Motif Chemokine 6; Chemokine Alpha 3

Size Price Availability Quantity
10ug USD 210  USD210 In stock
50ug USD 530  USD530 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Chemokine (C-X-C-motif) ligand 6 (CXCL6) is a small cytokine in the CXC chemokine family. It is a potent neutrophil chemoattractant and activator, and it shares broad similarities with other CXC chemokines such as IL-8 and ENA-78. CXCL6 promoted the release of MMP-9 from granulocytes, indicating its potential role as an inflammatory mediator. It functionally uses the IL-8/CXCL8 receptor to chemotaxis neutrophils, but this is structurally related to the epithelal-derived neutrophil attractor 78 (ENA-78)/CXCL5. The human CXCL6 gene has been cloned and physically mapped to the CXC chemokine locus on chromosome 4. Mature human CXCL6 is a 75-amino acid (AA) protein with a predicted molecular weight of approximately 8 kDa. The homology of human CXCL6 to mouse and bovine CXCL6 was 60% and 67%, respectively.

Recombinant Human C-X-C Motif Chemokine 6 expressed the target gene encoding Gly38-Asn114 with a 6His tag at the C-terminus.


Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, 1mM EDTA, pH 7.4.


Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Xiaolin Wang, et al. Cancer Biol Ther. CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation

[2] W Shen, et al. Eur Rev Med Pharmacol Sci. MicroRNA-101-5p inhibits the growth and metastasis of cervical cancer cell by inhibiting CXCL6

[3] Jia-Chi Ma, et al. World J Gastroenterol. Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer

[4] H Zhang, et al. Hum Reprod. The chemokine CXCL6 restricts human trophoblast cell migration and invasion by suppressing MMP-2 activity in the first trimester

[5] Helena M Linge, et al. Antimicrob Agents Chemother. The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial

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Keywords: Recombinant Human CXCL6 (HEK293, C-6His), C-X-C Motif Chemokine 6; Chemokine Alpha 3 supplier, Cytokines and Growth Factors, inhibitors, activators

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