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Recombinant Mouse IL-1β (E. coli)

Cat. No. M11191

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse IL-1β (E. coli) Structure
Synonym:

IL1B; IL-1; IL1-BETA

Size Price Availability Quantity
10ug USD 210  USD210 In stock
50ug USD 770  USD770 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Interleukin-1 Beta (IL-1β) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. ED50 < 10.0 pg/ml, measured by the dose-dependent stimulation of mouse D10.G4.1 helper T cells, corresponding to a specific activity of 1.0 × 108 IU/mg. 


Accession #: P10749 

Apparent Molecular Weight: ~17.5 kDa, on SDS-PAGE under reducing conditions. 

Endotoxin Level: < 0.2 EU/μg of protein by gel clotting method 

Lyophilized after extensive dialysis against PBS.

Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C.
References

[1] Jun Jacob Hu, et al. Nat Immunol. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

[2] Zhen Wang, et al. Autophagy. Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation

[3] Jan Petrasek, et al. J Clin Invest. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

[4] Nobuhiko Kayagaki, et al. Nature. Non-canonical inflammasome activation targets caspase-11

[5] Rongbin Zhou, et al. Nat Immunol. Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Keywords: Recombinant Mouse IL-1β (E. coli), IL1B; IL-1; IL1-BETA supplier, Cytokines and Growth Factors, inhibitors, activators

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