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Fosaprepitant dimeglumine salt

Cat. No. M2712
Fosaprepitant dimeglumine salt Structure
Synonym:

MK-0517

Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 180  USD180 In stock
100mg USD 780  USD780 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Fosaprepitant is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1004.83
Formula C23H22F7N4O6P.2C7H17NO5
CAS Number 265121-04-8
Purity >98%
Solubility DMSO 190 mg/mL
Storage at -20°C
References

[1] S Weibel, et al. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: an abridged Cochrane network meta-analysis

[2] Stephanie Weibel, et al. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

[3] Randy Erickson, et al. Hydration requirements in patients receiving highly emetogenic chemotherapy

[4] Susan Sun, et al. Compatibility of intravenous fosaprepitant with intravenous 5-HT3 antagonists and corticosteroids

[5] M Bayes, et al. Gateways to clinical trials

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Fosaprepitant dimeglumine salt, MK-0517 supplier, inhibitors

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