| Cat.No. | Name | Information |
|---|---|---|
| M2206 | TH-302 (Evofosfamide) | TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM. |
| M6098 | Baicalein | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor, IC50 value of 3.12 mM. |
| M9325 | EGTA | EGTA is a specific calcium chelator with a Kd of 60.5 nM at physiological pH (7.4) and a high specificity for Ca2+ than for Mg2+.EGTA significantly inhibits the substrate adhesion capacity of inflammatory macrophages. |
| M9330 | Brij-35 | Brij-35 (Polidocanol) is a high HLB, ethoxylated, nonionic ether of lauryl alcohol with broad pH stability. |
| M6154 | 2-PMPA tetrasodium | 2-PMPA (PMPA tetrasodium salt) is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM. |
| M2250 | Pamidronate disodium | Pamidronate disodium is a nitrogen containing bisphosphonate, used to the research of preventing osteoporosis. |
| M9916 | DPPH | DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that measures the free radical scavenging activity of antioxidants. |
| M9194 | Insulin (human) | Insulin (human) is a polypeptide hormone that regulates the level of sugar (glucose) in the blood and is produced by beta cells of islets. |
| M3409 | Formestane | Formestane is a second generation selective aromatase inhibitor with an IC50 of 80 nM. |
| M9665 | N-(2-amino-2-oxoethyl)acrylamide | N-(2-Amino-2-oxoethyl)acrylamide |
| M8731 | ASB14780 | ASB14780 is an indole-based selective and potent cytosolic phospholipase A2α inhibitor (IC50 = 20 nM/cPLA2α and >10 μM/sPLA2α). |
| M8730 | INI-43 | INI-43 is a cell penetrant and potent inhibitor of Kpnb1-mediated nuclear import that cancer cell death via a G2–M cell cycle arrest followed by apoptosis. |
| M8727 | IMB5046 | IMB5046 is a microtubule inhibitor that has antitumor activity, overcoming multidrug-resistance. |
| M8726 | ISAM-140 | ISAM-140 is a potent and selective A2B adenosine receptor antagonist (A2BAR). |
| M8724 | NSC73306 | NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells. |
| M8723 | PBOX-15 | PBOX-15 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 155 nM/HL60-MDR1, 252 nM/HL60-ABCG2, 210 nM/HL60). |
| M8722 | SYP-5 | SYP-5 is potent and selective inhibitor of HIF-1 activity that decreases HIF-1α and HIF-1β protein levels under hypoxic condition. |
| M8719 | MK204 | MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). |
| M8718 | VPC-13566 | VPC-13566 is Binding Function 3 (BF3)-specific inhibitor of the androgen receptor. |
| M8717 | PBOX-6 | PBOX-6 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 2. |
| M8716 | SPL-334 | SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR), the enzyme responsible for regulating cellular concentrations of S-Nitrosoglutathione (GSNO), which plays a critical role in nitric oxide signaling in the respiratory tract. |
| M8715 | GNF-1331 | GNF-1331 is an orally available, potent and selective Porcupine (PORCN) inhibitor. |
| M8714 | DM-NOFD | DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF). |
| M8713 | ORM-3819 | ORM-3819 is a potent inotropic agent that binds to cardiac troponin C (cTnC) and sensitizes heart to Ca2+. |
| M8712 | KIN1400 | KIN1400 is innate immune agonists of IRF3 activation that induces IRF3 and MAVS dependent innate immune antiviral genes and IFNβ expression. |
| M8709 | KIN1408 | KIN1408 is a small molecule that targets factors at or above the level of MAVS in the RLR signaling pathway to drive IRF3 activation (IRF3 nuclear translocation ECmax = 5 μM in 20 h; Huh7 cells) without significant cytotoxicity (50 μM/20 h in Huh7 or 20 μM/36 h in HEK293 cultures). |
| M8708 | Rbin-2 | Rbin-2 (ribozinoindole-2) is a cell penetrant, potent, selective and reversible inhibitor of Midasin that inhibits eukaryotic ribosome biogenesis. |
| M8707 | OUL35 | OUL35 is a cell penetrant, potent and selective ARTD10/PARP10 inhibitor. |
| M8706 | NSC57969 | NSC57969 is a MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. |
| M8705 | J104129 fumarate | J104129 is a muscarinic M3 receptor antagonist greater than 100-fold selectivity for M3 over M2 receptors. |
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