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PBOX-15

Cat. No. M8723

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PBOX-15 Structure

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Biological Activity

PBOX-15 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 155 nM/HL60-MDR1, 252 nM/HL60-ABCG2, 210 nM/HL60). PBOX-15 inhibits the assembly of purified tubulin in cell-free assays and causes microtubule depolymerization in MCF-7 cells.

Chemical Information
Molecular Weight 417.46
Formula C28H19NO3
CAS Number 354759-10-7
Solubility (25°C) DMSO: 15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] No authors listed. Eur J Pharmacol. Retraction notice to “PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines” [Eur. J. Pharmacol. 714(1–3) (2013) 379–387]

[2] Giuseppina Gangemi, et al. PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines

[3] Joanne Lysaght, et al. The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells

[4] E N Maginn, et al. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells

[5] James C Forde, et al. Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro

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Keywords: PBOX-15 supplier, inhibitors, activators

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