Pamidronate disodium is a nitrogen containing bisphosphonate used to prevent bone loss, and treat osteoporosis. Pamidronate disodium is also used as an experimental treatment of the bone disorder known as Osteogenesis Imperfecta, brittle bones and fragile fatigues.
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Pamidronate disodium purchased from AbMole
| Molecular Weight | 279.03 |
| Formula | C3H9NNa2O7P2 |
| CAS Number | 57248-88-1 |
| Solubility (25°C) | Water 6 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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