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J104129 is a muscarinic M3 receptor antagonist greater than 100-fold selectivity for M3 over M2 receptors. Its Ki for M3 receptors = 4.2 nM compared to a Ki of 490 nM for M2 receptors. J-104129 showed potent bronchodilator activity in animal studies.
| Molecular Weight | 500.63 |
| Formula | C24H36N2O2 · C4H4O4 |
| CAS Number | 257603-40-0 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Alexey I Evseev, et al. Functional effects of KCNQ K(+) channels in airway smooth muscle
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