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Animal Modeling

Cat.No.  Name Information
M1969 Doxorubicin HCL Doxorubicin HCl (Adriamycin, DOX, RP 13057) hydrochloride is an antibiotic-like agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
M2082 Streptozotocin Streptozotocin (STZ) is a kind of glucosamine - nitrosourea derivative. *The compound is unstable in solutions, freshly prepared is recommended
M2227 Imiquimod Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is a selective toll like receptor 7 (TLR7) agonist. with potent indirect antiviral activity.
M5152 Sodium Butyrate Sodium butyrate is the sodium salt of butyric acid, which has been reported to cause hyperacetylation of histones due to its role as a HDAC inhibitor with IC50 values of 0.3, 0.4, 0.3 mM for HDAC1, 2 and 7 respectively. Can be used to construct animal models of venous stenosis.
M3637 Puromycin dihydrochloride Puromycin dihydrochloride is an aminonucleoside antibiotic that acts as a protein synthesis inhibitor.
M3699 Letrozole Letrozole is an orally active, potent, selective, nonsteroidal, third-generation aromatase (CYP19A1) inhibitor, a synthetic benzyltriazole derivative, which is used in the construction of animal models of polycystic ovary syndrome (PCOS), as well as in studies related to postoperative hormone-responsive breast cancer.
M5688 Heparin sodium Heparin sodium salt, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule.
M9524 Lipopolysaccharides Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. This product is derived from Escherichia coli O55:B5.
M6209 Rotenone Rotenone is an inhibitor of mitochondrial electron transport at NADH:ubiquinone oxidoreductase, and is used to induce a Parkinson-like syndrome as an experimental model in rats.
M3671 Cyclophosphamide monohydrate Cyclophosphamide monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA. *The compound is unstable in solutions, freshly prepared is recommended
M4914 Tyloxapol Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction.
M4663 Reserpine Reserpine is an inhibitor of vesicular monoamine transporter protein 2 (VMAT2) that irreversibly blocks the H+-coupled vesicular monoamine transporters, VMAT1 and VMAT2. It can be used to construct animal models of depression.
M4282 Monocrotaline Monocrotaline (Crotaline) is an pyrrolizidine alkaloid extracted from the seeds of the Crotalaria spectabilis plant to induce pulmonary hypertension in rodents.
M3891 Calcipotriol Calcipotriol is a 1,25-Dihydroxyvitamin D3 analogue which is used for the research of psoriasis. *The compound is unstable in solutions, freshly prepared is recommended
M3738 Oxonic acid potassium salt Oxonic acid potassium salt is an inhibitor of uricase.
M3521 Fluticasone propionate Fluticasone propionate (Flonase, Veramyst) is a synthetic corticosteroid which is derived from fluticasone used to treat asthma and allergic rhinitis (hay fever).
M3463 Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. It can be used to construct autoimmune hepatitis models.
M3453 Scopolamine hydrobromide Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.It can be used to construct animal models of dry eye.
M3384 Diethylstilbestrol Diethylstilbestrol is a synthetic nonsteroidal estrogen that can be used to construct animal models of primary dysmenorrhea.
M3325 Captopril Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM. It can be used to construct animal models of heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM.
M3301 Acetaminophen Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. *The compound is unstable in solutions, freshly prepared is recommended
M3232 Cortisone acetate Cortisone acetate is the acetate form of Cortisone, a steroid hormone and glucocorticoid that suppresses the immune system, thereby reducing inflammatory pain and swelling at the site of injury.Cortisone acetate and epinephrine, the primary hormones released by the body in response to stress, elevate blood pressure. They can be used to construct animal models of hypertension.
M3215 Adenine Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.
M3186 Isoprenaline hydrochloride Isoproterenol hydrochloride is a non-selective β-adrenoceptor, inhibits the 3H-inositol phosphate accumulation with IC50 of 0.08 μM.
M2944 Pilocarpine hydrochloride Pilocarpine hydrochloride is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. *The compound is unstable in solutions, freshly prepared is recommended
M2683 Estradiol Benzoate Estradiol Benzoate is an estrogen analog and an estrogen receptor (ER) agonist that binds to human, murine, and chicken ERα with an IC50 in the range of 22-28 nM.In addition, Estradiol Benzoate can be used in animal disease models (e.g., rat bacterial vaginitis model, rat prostatitis model, etc.). Construct.
M2626 Dexamethasone Sodium Phosphate Dexamethasone Sodium Phosphate is a glucocorticoid receptor agonist that induces the production of lipocortin, a phospholipase A2 inhibitory protein. Dexamethasone inhibits autophagy levels in damaged cells in a dose-dependent manner. It can be used to construct models of allergic conjunctivitis.
M2625 Dexamethasone acetate Dexamethasone acetate is a potent glucocorticoid-like synthetic that inhibits the pituitary-adrenal axis. It can be used to construct animal models of atopic dermatitis.
M2619 Deoxycorticosterone acetate Deoxycorticosterone acetate, an adrenocorticotropic hormone and also a precursor of aldosterone, as well as a salicorticoid receptor (MR) agonist, can be used to construct rat models of hypertension.
M2548 Cysteamine hydrochloride Cysteamine HCl, the hydrochloride form of Cysteamine, is also a transglutaminase 2 (TGM2) inhibitor, which can be used to induce gastrointestinal disorders in a mouse model as well as a duodenal ulcer model. In addition, Cysteamine HCl has the ability to modulate the activity of dopamine neurons in the striatum of awake, freely moving rats by inhibiting the increased dopamine release from amphetamine, and has antioxidant activity.




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