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Scopolamine hydrobromide

Cat. No. M3453
Scopolamine hydrobromide Structure
Synonym:

(-)-Scopolamine hydrobromide; Hyoscine hydrobromide; Scopine hydrobromide

Size Price Availability Quantity
50mg USD 36  USD40 In stock
100mg USD 45  USD50 In stock
500mg USD 121.5  USD135 In stock
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Quality Control
Biological Activity

Scopolamine is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM. It is a tropane alkaloid compound with muscarinic antagonist effects. It is among the secondary metabolites of plants from Solanaceae (nightshade) family of plants, such as henbane, jimson weed and Angel’s Trumpets (Datura resp. Brugmansia spec.), and corkwood (Duboisia species). It exerts its effects by acting as a competitive antagonist at muscarinic acetylcholine receptors, specifically M1 receptors; it is thus classified as an anticholinergic, anti-muscarinic drug.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 384.26
Formula C17H21NO4.HBr
CAS Number 114-49-8
Purity 100.0%
Solubility Water ≥ 50 mg/mL
DMSO ≥ 50 mg/mL
Storage 2-8°C, dry, sealed
References

Neuromodulatory propensity of Bacopa monniera against scopolamine-induced cytotoxicity in PC12 cells via down-regulation of AChE and up-regulation of BDNF and muscarnic-1 receptor expression
M D Pandareesh, et al. Cell Mol Neurobiol. 2013 Oct;33(7):875-84. PMID: 23824529.

Egg yolk phosphatidylcholine: Extraction, purification and its potential neuroprotective effect on PC12 cells
Jin Chen, et al. J Funct Foods. 2019 Mar;56:372-383.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Scopolamine hydrobromide, (-)-Scopolamine hydrobromide; Hyoscine hydrobromide; Scopine hydrobromide supplier, AChR/AChE, inhibitors

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