Heparin sodium salt (MW 15kDa) is a heparin polymer with a molecular weight of 15kDa.Heparin sodium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII), thereby accelerating the rate of inactivation of Thrombin factor IIa and factor Xa by ATIII. Heparin sodium salt is used for blood collection and plasma preparation in experimental animals and for the construction of parenteral nutrition models in mice.
| Molecular Weight | 15000 |
| Formula | (C14H25NO20S3)n.xNa |
| CAS Number | 9041-08-1 |
| Form | Solid |
| Solubility (25°C) | Water 20 mg/mL |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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