All AbMole products are for research use only, cannot be used for human consumption.
Letrozole is an orally active, potent, selective, nonsteroidal, third-generation aromatase (CYP19A1) inhibitor, a synthetic benzyltriazole derivative, which is used in the construction of animal models of polycystic ovary syndrome (PCOS), as well as in studies related to postoperative hormone-responsive breast cancer.
EMBO Mol Med. 2023 Dec.
MYSM1 acts as a novel co-activator of ERα to confer antiestrogen resistance in breast cancer
Letrozole purchased from AbMole
J Steroid Biochem Mol Biol. 2013 Nov;138:54-62.
Effect of androgens on different breast cancer cells co-cultured with or without breast adipose fibroblasts
Letrozole purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Human breast cancer cells MCF-7 |
| Preparation method | Seeding cells in duplicate at 5,000 to 10,000 cells per well in 24-well plates. The day after plating,adding different concentrations of Letrozole . At the end of incubation, trypsinizating cells and placing in Isotone solution and counting immediately using a Coulter particle-counter. |
| Concentrations | ~100 nM |
| Incubation time | 1 days |
| Animal Experiment | |
|---|---|
| Animal models | Human breast carcinoma xenografts MCF-7 with human aromatase gene (MCF-7Ca) |
| Formulation | 0.5% (w/v) solution of carboxymethylcellulos |
| Dosages | 20 mg/kg/day |
| Administration | orally administered by gavage once every 2 days |
| Molecular Weight | 285.30 |
| Formula | C17H11N5 |
| CAS Number | 112809-51-5 |
| Solubility (25°C) | DMSO ≥ 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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