About 31 results found for searched term "T-F-Q-A-Y-P-L-R-E-A" (0.066 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M50993 | T-F-Q-A-Y-P-L-R-E-A | Others |
| T-F-Q-A-Y-P-L-R-E-A is a peptide. | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2167 | (+)-JQ1 | Epigenetic Reader Domain |
| JQ1 | ||
| (+)-JQ1 is a BET bromodomain inhibitor that acts on BRD4(2) with an IC50 of 33 nM and binds to all bromodomain domains in the BET family, but not to bromodomain domains outside the BET family. JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway, and JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway. | ||
| M2800 | KY02111 | Others |
| KY02111 is a widely used small molecule that boosts cardiomyogenesis. Chemical genetics of KY02111 identified squalene synthase (SQS) as a molecular target of KY02111. By disrupting the interaction of SQS with cardiac ER-membrane protein TMEM43, KY02111 impairs TGFβ/SMAD signaling and recapitulates the clinical mutation of TMEM43 that causes an inherited heart disease. | ||
| M3720 | Moxifloxacin | Topoisomerase |
| Moxifloxacin is an extended-spectrum fluoroquinolone which has improved coverage against gram-positive cocci and atypical pathogens compared with older fluoroquinolone agents, while retaining good activity against gram-negative bacteria. | ||
| M3892 | BMH-21 | DNA/RNA Synthesis |
| BMH-21 is a first-in-class DNA intercalator that binds to high-frequency GC-rich sequences in ribosomal DNA genes and can effectively and rapidly inhibit the transcription of RNA polymerase I (Pol I), leading to degradation of the Pol I catalytic subunit RPA194 and non-phosphorylation of histone H2AX. H2AX is not phosphorylated.BMH-21 has broad and potent antitumor activity in NCI60 cancer cell line and inhibits tumor growth in vivo. | ||
| M3896 | Ro 48-8071 | Others |
| Ro 48-8071 is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity. | ||
| M3924 | Scrambled 10Panx | Peptides |
| Scrambled 10Panx is the scrambled form of 10Panx (WRQAAFVDSY), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents. | ||
| M4003 | Isoquercitrin | Wnt/beta-catenin |
| Quercetin 3-glucoside; IQ | ||
| Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. | ||
| M4049 | Complanatoside-A | Others |
| Complanatoside A is A flavonol glycoside isolated from Astragalus membranaceus, which is currently used as the quality control index of A. complanatus 2010 edition of Chinese Pharmacopoeia. | ||
| M4064 | Pseudoginsenoside-F11 | Metabolite/Endogenous Metabolite |
| Ginsenoside A1 | ||
| Pseudoginsenoside F11 (Ginsenoside A1), a component of Panax quinquefolium, can resist the learning and memory impairment induced by scopolamine, morphine and methamphetamine in mice. | ||
| M4108 | 25-Methoxyalisol-A | Others |
| 25-O-methylalisol A is A sterane triterpenoid isolated from Alisma orientale. The dried roots of the aquatic plant Alismatis Alismatis, known as Rhisoma Alismatis, are commonly used in traditional Chinese medicine for diuretic, anti-inflammatory and lipid-lowering studies, as well as diabetes. | ||
| M4210 | EGC | MMP |
| EGC; Epigallocatechin; l-Epigallocatechin; epi-Gallocatechin | ||
| EGC is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils. | ||
| M4382 | Artemisinine | Akt |
| Qinghaosu; NSC 369397 | ||
| Artemisinin (Qinghaosu) is a kind of sesquiterpene lactone, an antimalarial drug isolated from the aboveground part of Artemisia annua L. Artemisinin inhibits AKT signaling by decreasing pAKT in a dose-dependent manner. Artemisinin can reduce the proliferation, migration, invasion, tumorigenesis and metastasis of cancer cells, and Artemisinin has neuroprotective effects. | ||
| M4883 | RO 48-8071 fumarate | Others |
| 4012AH | ||
| Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity. | ||
| M5000 | Berberine chloride | Antibiotic |
| Natural Yellow 18 chloride | ||
| Berberine chloride (Natural Yellow 18 chloride) is a quaternary ammonium salt of isoquinoline alkaloids. It's an alkaloid, commonly used as an antibiotic. It can effectively inhibit the proliferation of various cancer cells and promote cell apoptosis. It has antitumor properties. | ||
| M5132 | Quinacrine Dihydrochloride Dihydrate | Parasite |
| Quinacrine Hydrochloride Hydrate (Mepacrine Hydrochloride) is an antimalarial that has anti-tumor effects in vivo and in vitro. Quinacrine hydrochloride hydrate inhibits NF-κB, activates p53 signal transduction and induces apoptosis in tumor cells. | ||
| M5674 | Garenoxacin Mesylate hydrate | Antibiotic |
| Garenoxacin mesylate hydrate is a novel oral des-fluoro(6) quinolone with potent antimicrobial activity, against common respiratory pathogens, including resistant strains. | ||
| M5899 | Procaine | Animal experimental anesthetics |
| Novocaine, Vitamin H3, Duracaine, Spinocaine | ||
| Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M5913 | Quizalofop-p-ethyl | Others |
| (R)-Quizalofop ethyl; Quinofop-ethyl | ||
| Quizalofop-P-ethyl is a slightly toxic, selective, postemergence phenoxy herbicide, used to control annual and perennial grass weeds in potatoes, soybeans, sugar beets, peanuts vegetables, cotton and flax. Quizalofop-P-ethyl is absorbed from the leaf surface and is moved throughout the plant. Quizalofop-P-ethyl accumulates in the active growing regions of stems and roots. | ||
| M6238 | Lanolin | Adjuvants |
| Wool fat | ||
| Lanolin is a complex waxy substance composed of varying quantities of long-chain waxy esters and lanolin alcohols, acids and polycarbons, used as adjuvant. | ||
| M6240 | Angiotensin II human | Animal Modeling |
| Angiotensin II; Hypertensin II; Ang II; DRVYIHPF | ||
| Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. Keep away from light and prepare for use now. | ||
| M6866 | KL 001 | Others |
| KL 001 is a first-in-class cryptochrome protein (CRY) stabilizer that interacts specifically with CRY1 and CRY2 to prevent ubiquitin-dependent CRY degradation, thereby prolonging the circadian cycle. In addition, KL001 has the potential to control fasting hormone-induced gluconeogenesis. | ||
| M7177 | Quinine hydrochloride | Potassium Channel |
| Quinine hydrochloride is the hydrochloride form of Quinine, an alkaloid extracted from the bark of the cinchona tree, with antimalarial and antitumor activities, and an IC50 value of 60 ng/mL against P. falciparum strains passou and 107.8 ng/mL against P. falciparum strain 3CD7, respectively, and an inhibitor of potassium channels. Quinine hydrochloride is also a potassium channel inhibitor that inhibits voltage pulse-induced MT mSlo3 (KCa5.1) channel +100 mV currents, with an IC50 value of 169 μM. In addition, Quinine hydrochloride binds to purine nucleoside phosphorylase (PfNP) and PfNP with low nanomolar affinity. nucleoside phosphorylase (PfPNP) with low nanomolar affinity. | ||
| M7189 | Resiquimod | TLR |
| R848; S28463 | ||
| Resiquimod (R-848) is a agonist of Toll-like receptors 7 and 8 (TLR7/TLR8) that induces upregulation of cytokines such as TNF-α, IL-6 and IFN-α. R848 (Resiquimod) induces differential TLR7 and/or TLR8 responses in human and murine immune cells. R848 (Resiquimod) acts as a selective activating ligand for both TLR7 and TLR8 in humans but only TLR7 in mice. It activates immune cells via the TLR7/TLR8 MyD88-dependent signaling pathway with the subsequent activation of the transcription factors NF-κB and interferon regulatory factor (IRF). | ||
| M7658 | BTA-1 | Others |
| BTA-1 is a probe for β-amyloid aggregates; fluorescent thioflavin-T derivative; exhibits high affinity for amyloid deposits; displays 50-fold higher affinity than thioflavin-T; selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice, as well as Aβ fibrils in postmortem brain tissue obtained from AD patients; crosses the blood brain barrier. | ||
| M8124 | Quinine hemisulfate salt monohydrate | Potassium Channel |
| Quinine hemisulfate salt monohydrate is a potassium channel inhibitor that inhibits voltage pulse-induced currents in the MT mSlo3 (KCa5.1) channel +100 mV with an IC50 of 169 μM.In addition, Quinine hemisulfate salt monohydrate binds to purine nucleoside phosphorylase (PfPNP) with low nanomolar affinity. In addition, Quinine hemisulfate salt monohydrate binds to purine nucleoside phosphorylase (PfPNP) with low nanomolar affinity. | ||
| M8473 | RA-9 | Others |
| RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. | ||
| M9267 | Coelenterazine | Fluorescent Dye |
| CTZ; CLZN | ||
| Coelenterazine is the luciferin, the light-emitting molecule, used for monitoring reporter genes in BRET, ELISA and HTS techniques.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M8860 | X80 | DNA/RNA Synthesis |
| X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair. | ||
| M9631 | FITC | Fluorescent Dye |
| 5-FITC; 5-Isothiocyanato fluorescein; FITC isomer I | ||
| FITC (Fluorescein Isothiocyanate, 5-FITC) is an amine-reactive reagent for the FITC labeling of proteins, microsequencing of proteins, and peptides. The isothiocyanate group of FITC can be combined with amino, sulfhydryl, imidazole, tyrosyl, carbonyl and other groups on the protein, so as to achieve protein labeling including antibodies and lectins. | ||
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