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Ro 48-8071 blocked human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; in cells it triggered the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol. Administration of Ro 48-8071 to mice with BT-474 tumor xenografts prevented tumor growth, with no apparent toxicity. Ro 48-8071 degraded ERα while concomitantly inducing the anti-proliferative protein ERβ.
| Molecular Weight | 564.44 |
| Formula | C27H31BrFNO6 |
| CAS Number | 189197-69-1 |
| Solubility (25°C) | DMSO 55 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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