Scrambled 10Panx is the scrambled form of 10Panx (WRQAAFVDSY), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents.
| Cell Experiment | |
|---|---|
| Cell lines | MDA-231, and BT-20 cells |
| Preparation method | Exposing cells to various concentrations of 10-Hydroxycamptothecin for 72 hours. Monitoring cell growth by the standard MTT assay. |
| Concentrations | Dissolved in DMSO, final concentrations ~50 μM |
| Incubation time | 72 hours |
| Animal Experiment | |
|---|---|
| Animal models | BALB/c-nu mice transplanted subcutaneously with Colo 205 cells |
| Formulation | Dissolved in propylene glycol |
| Dosages | ~7.5 mg/kg |
| Administration | Orally once per two days |
| Molecular Weight | 1242.37 |
| Formula | C58H79N15O16 |
| CAS Number | 1315378-72-3 |
| Solubility (25°C) | DMSO ≥ 24 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Peptides Products |
|---|
| Elcatonin
Elcatonin is a synthetic analog of eel calcitonin that increases bone density and inhibits bone resorption. |
| Pegmolesatide
Pegmolesatide is a synthetic peptide-based erythropoietic agent that may be used in studies related to anemia in chronic kidney disease. |
| Trofinetide
Trofinetide, a water-soluble analog of glycine-proline-glutamic acid (GPE), uses the unnatural amino acid 2-methylproline in place of the proline found in the natural compound, and works by enhancing synaptic activity, restoring synaptic structure, inhibiting the effects of inflammatory compounds in the brain, increasing antioxidant responses, reducing injury-induced cell death, and increasing central IGF-1 presence. It has neuroprotective activity and can be used in studies related to Rett syndrome. |
| Hemopressin (human, mouse)
Hemopressin is a natriuretic peptide derived from the α1 chain of hemoglobin, originally isolated from rat brain homogenates. Hemopressin is also an orally potent, selective inverse agonist at the CB1 cannabinoid receptor.Hemopressin has anti-injury sensory effects in models of inflammatory pain. |
| Trypsin Inhibitor (from Soybean)
Trypsin inhibitor is an alkaline polypeptide consisting of 58 amino acid residues with a pear shape throughout the molecule and a lysine activity center. It can compete with the activity center of many proteases for a lysyl group and inhibit their activities. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
