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Katacalcin TFA (PDN 21 TFA) is a potent plasma calcium-lowering peptide. Katacalcin belongs to the calcitonin family, that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of these ions in the bones. Katacalcin elicites concentration-dependent migration of CD14+ PBMC at concentrations from the atomolar to the micromolar range and deactivates attractant-induced chemotaxis. Katacalcin regulates human CD14+ PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways.
| Molecular Weight | 2550.62 |
| Formula | C99H155F3N34O38S2 |
| CAS Number | 85916-47-8 (free base) |
| Solubility (25°C) | Water |
| Storage | -20°C, sealed |
[2] C J Hillyard, et al. Lancet. Katacalcin: a new plasma calcium-lowering hormone
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