KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
|Source||Exp Eye Res (2015). Figure 2. KY02111|
|Cell Lines||HTM cells|
|Incubation Time||8 days|
|Results||When HTM cells were treated with SFRP1 (0.5 μg/mL) and a small molecular inhibitor (10 μM KY02111), there was a substantial increase in T41 phosphorylation, indicating Wnt inhibition|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO 55 mg/mL|
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