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Cat. No. M2800
KY02111 Structure
Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 70  USD70 In stock
50mg USD 270  USD270 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.

Customer Product Validations & Biological Datas
Source Exp Eye Res (2015). Figure 2. KY02111
Method Western blot
Cell Lines HTM cells
Concentrations 10 μM
Incubation Time 8 days
Results When HTM cells were treated with SFRP1 (0.5 μg/mL) and a small molecular inhibitor (10 μM KY02111), there was a substantial increase in T41 phosphorylation, indicating Wnt inhibition
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 376.86
Formula C18H17ClN2O3S
CAS Number 1118807-13-8
Purity >98%
Solubility DMSO 55 mg/mL
Storage at -20°C

[1] Yasushi Takemoto, et al. Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis

[2] Yoshiteru Yano, et al. Non-neural and cardiac differentiating properties of Tbx6-expressing mouse embryonic stem cells

[3] Joshua T Morgan, et al. Wnt inhibition induces persistent increases in intrinsic stiffness of human trabecular meshwork cells

[4] Itsunari Minami, et al. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions

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Keywords: KY02111 supplier, Wnt/beta-catenin, inhibitors

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