Free shipping on all orders over $ 500

KY02111

Cat. No. M2800
KY02111 Structure
Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 70  USD70 In stock
50mg USD 270  USD270 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.

Customer Product Validations & Biological Datas
Source Exp Eye Res (2015). Figure 2. KY02111
Method Western blot
Cell Lines HTM cells
Concentrations 10 μM
Incubation Time 8 days
Results When HTM cells were treated with SFRP1 (0.5 μg/mL) and a small molecular inhibitor (10 μM KY02111), there was a substantial increase in T41 phosphorylation, indicating Wnt inhibition
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 376.86
Formula C18H17ClN2O3S
CAS Number 1118807-13-8
Purity >98%
Solubility DMSO 55 mg/mL
Storage at -20°C
References

[1] Yasushi Takemoto, et al. Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis

[2] Yoshiteru Yano, et al. Non-neural and cardiac differentiating properties of Tbx6-expressing mouse embryonic stem cells

[3] Joshua T Morgan, et al. Wnt inhibition induces persistent increases in intrinsic stiffness of human trabecular meshwork cells

[4] Itsunari Minami, et al. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions

Related Wnt/beta-catenin Products
Tegatrabetan

Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1).

CWP232228

CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus.

β-catenin-IN-2

β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer.

YB-0158

YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities.

Pyrvinium pamoate

Pyrvinium pamoate is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling.

  Catalog
Abmole Inhibitor Catalog




Keywords: KY02111 supplier, Wnt/beta-catenin, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.