Free shipping on all orders over $ 500

RA-9

Cat. No. M8473

All AbMole products are for research use only, cannot be used for human consumption.

RA-9 Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. RA-9 directly inhibits activity of following DUB UCH-L1, UCH-L3, USP2, USP5 and USP8 deubiquitinating enzymes, which results in rapid accumulation of poly-ubiquitinated proteins leading to cell cycle checkpoint arrest and tumor cell apoptosis.

Chemical Information
Molecular Weight 365.34
Formula C19H15N3O5
CAS Number 919091-63-7
Solubility (25°C) DMSO: 2 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Donatella Treppiedi, et al. USP8 inhibitor RA-9 reduces ACTH release and cell growth in tumor corticotrophs

[2] Katie Wan Yee Yeung, et al. Current understanding of potential ecological risks of retinoic acids and their metabolites in aquatic environments

[3] Charlotte J C Edwards-Gayle, et al. Self-Assembly, Antimicrobial Activity, and Membrane Interactions of Arginine-Capped Peptide Bola-Amphiphiles

[4] Mayako Fujihara, et al. Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9

[5] Kathleen Coughlin, et al. Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses

Related Products
PCL-PEG-MAL

PCL-PEG-MAL is an amphiphilic block copolymer consisting of polycaprolactone (PCL), polyethylene glycol (PEG) and maleimide (MAL) functional groups. PCL-PEG-MAL is used in targeted delivery systems, surface modification of nanomaterials, functionalisation of biomaterials and biosensing technologies for specific chemical linkages or biomolecular immobilisation.
DSPE-PEG-Streptavidin

DSPE-PEG-Streptavidin is an important biocoupling molecule widely used in biomedical research, especially in drug delivery, targeted therapies, immunodiagnostics and biosensors. Through the specific binding between streptavidin and biotin, DSPE-PEG-Streptavidin can help to achieve efficient loading and targeted action in targeted delivery systems. In addition, the molecule is widely used in molecular imaging and bioassays, especially for molecular recognition using the strong affinity between streptavidin and biotin in assay platforms that require high sensitivity and specificity.
E7107

E7107 is a first-in-class precursor messenger ribonucleic acid (pre-mRNA) spliceosome inhibitor.
KL044

KL044 is a stabilizer of the clock protein cryptochrome (CRY). KL044 is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity.
2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide

2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide is a biochemical material that can be used in scientific research.
  Catalog
Abmole Inhibitor Catalog




Keywords: RA-9 supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.