About 30 results found for searched term "RA-9" (0.04 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1674 | BIBR 953 | Thrombopoietin/Thrombin |
| Dabigatran, Pradaxa; BIBR 953ZW | ||
| BIBR 953 (Dabigatran, Pradaxa) is an oral anticoagulant from the class of the direct thrombin inhibitors. | ||
| M1721 | AZD4547 | FGFR |
| Fexagratinib; ABSK091 | ||
| AZD4547 is a potent, selective and orally active pan-FGFR inhibitor with IC50s of 0.2. 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively. | ||
| M1956 | Apatinib mesylate | VEGFR/PDGFR |
| Rivoceranib mesylate; YN968D1 | ||
| Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor of VEGFR2 with an IC50 of 2.43 nM. | ||
| M2155 | (1S-cis)-Milnacipran Hydrochloride | 5-HT Receptor |
| Levomilnacipran hydrochloride; F-2695 hydrochloride | ||
| (1S-cis)-Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia. | ||
| M2257 | Levetiracetam | AChR/AChE |
| Keppra; UCB L059 | ||
| Levetiracetam (UCB L059) is an antiepileptic, it is also a selective M2 muscarinic acetylcholine receptors (mAChR) inhibitor. | ||
| M2468 | Brimonidine Tartrate | Adrenergic Receptor |
| Brimonidine tartrate; AGN190342 tartrate; UK14304 tartrate | ||
| Brimonidine Tartrate is a highly selective α-adrenergic receptor antagonist with an EC50 of 0.45 nM for α2A adrenoreceptor, and has been used to study open-angle glaucoma or ocular hypertension. | ||
| M3026 | Sorafenib (BAY 43-9006) | Raf |
| BAY 43-9006 | ||
| Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. | ||
| M3663 | K-Ras(G12C) inhibitor 9 | Ras |
| K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). | ||
| M3973 | Tazarotene | RAR/RXR |
| Tazorac; Zorac; AGN 190168 | ||
| Tazarotene (AGN 190168) is a new member of the acetylenic class of RARβ/γ selective retinoids which is approved to treat a variety of skin diseases, exhibits an anti-proliferative effect in human basal cell carcinoma (BCC) by triggering caspase-dependent apoptosis. | ||
| M4138 | Deucravacitinib (BMS-986165) | JAK |
| BMS986165 | ||
| Deucravacitinib (BMS-986165) is a first-in-class, selective, orally bioavailable inhibitor of TYK2 transitions.Deucravacitinib selectively binds the TYK2 pseudokinase (JH2) structural domain with an IC50 of 1.0 nM and a Ki value of 0.02 nM. Deucravacitinib (BMS-986165) blocks receptor-mediated Tyk2 activation by stably regulating the JH2 structural domain. deucravacitinib also inhibits the IL-12/23 and type I IFN pathways. deucravacitinib may be used in psoriasis research. | ||
| M4925 | Enoxacin hydrate | Antibiotic |
| Enoxacin sesquihydrate; AT-2266 hydrate; CI-919 hydrate | ||
| Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent. | ||
| M5231 | GSK2269557 | PI3K |
| Nemiralisib; GSK-2269557 | ||
| Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9). | ||
| M5323 | FRAX597 | PAK |
| FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively. | ||
| M5333 | Tirabrutinib (ONO-4059) | BTK |
| Tirabrutinib; GS-4059; Velexbru | ||
| Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM. | ||
| M5403 | Alvimopan dihydrate | Opioid Receptor |
| LY 246736 dihydrate; ADL 8-2698 dihydrate | ||
| Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). | ||
| M5564 | Desogestrel | Estrogen Receptor |
| Cerazette, Desogen, Desogestrelum, Org-2969 | ||
| Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. | ||
| M5806 | Nandrolone decanoate | Androgen Receptor |
| Deca Durabolin, 19-Nortestosterone decanoate, Retabolil | ||
| Nandrolone Decanoate is a mild form of an anabolic steroid. | ||
| M6053 | Vidarabine | DNA/RNA Synthesis |
| Ara-A; Arabinosyladenine; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine | ||
| Vidarabine is effective against herpes simplex virus and varicella-zoster virus. | ||
| M6170 | Bedaquiline fumarate | Antibiotic |
| R403323; TMC207 fumarate; R207910 fumarate | ||
| Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. | ||
| M6184 | Dutetrabenazine | Others |
| Tetrabenazine D6; Ro 1-9569 D6 | ||
| Deutetrabenazine is the deuterium labeled Tetrabenazine, which is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder. | ||
| M6293 | Tacrolimus monohydrate | Antibiotic |
| Fujimycin monohydrate; FR900506 monohydrate; FK506 monohydrate | ||
| Tacrolimus monohydrate binds to FK506 binding protein (FKBP). This complex inhibits calcineurin phosphatase (PP2B). Tacrolimus monohydrate is a mTOR-independent autophagy inducer. | ||
| M6528 | BRACO-19 trihydrochloride | DNA/RNA Synthesis |
| BRACO-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. | ||
| M7182 | RA 839 | Others |
| RA 839 is a nrf2 activator; inhibits Nrf2/Keap1 interaction. | ||
| M7423 | TRAM 39 | Others |
| TRAM 39 is a potent K Ca3.1 blocker. | ||
| M8033 | Paroxetine hydrochloride hemihydrate | 5-HT Receptor |
| BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate | ||
| Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant. | ||
| M8323 | Dexpramipexole dihydrochloride | Others |
| (R)-Pramipexole dihydrochloride; KNS 760704; SND 919CL2X | ||
| R-(+)-Pramipexole is a neuroprotective agent; weak non-ergoline dopamine agonist. | ||
| M8473 | RA-9 | Others |
| RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. | ||
| M8886 | RAF709 | Raf |
| RAF709 is a novel Raf kinase inhibitor with IC50 values of 0.4 and 1.5 nM for c-Raf and b-Raf, respectively. | ||
| M9428 | MRTX849 (Adagrasib) | Ras |
| Adagrasib; MRTX-849 | ||
| MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor. | ||
| M9577 | RA190 hydrochloride | Proteasome |
| RA190 HCl | ||
| RA190 HCl is a potent RPN13 and ADRM1 Inhibitor, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. | ||
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