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Tazarotene

Cat. No. M3973
Tazarotene Structure
Synonym:

Tazorac; Zorac; AGN 190168

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 50  USD50 In stock
10mg USD 50  USD50 In stock
50mg USD 165  USD165 In stock
100mg USD 290  USD290 In stock
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Quality Control & Documentation
Biological Activity

Tazarotene is a member of the acetylenic class of retinoids which binds at retinoid acid receptors (RAR) -β and -γ. Tazarotene is a retinoic acid receptor-specific retinoid with demonstrated efficacy in the topical treatment of psoriasis. Tazarotene exerts anti-inflammatory and immune-modulating activities toward both infective agents and damaged keratinocytes. Tazarotene down-regulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation. It is also up-regulates three novel genes TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which may mediate an antiproliferative effect.

Chemical Information
Molecular Weight 351.46
Formula C21H21NO2S
CAS Number 118292-40-3
Solubility (25°C) DMSO >30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Campione E, et al. Drug Des Devel Ther. Tazarotene as alternative topical treatment for onychomycosis.

[2] Wu CS, et al. DNA Cell Biol. Tazarotene induces apoptosis in human basal cell carcinoma via activation of caspase-8/t-Bid and the reactive oxygen species-dependent mitochondrial pathway.

[3] Duvic M, et al. J Am Acad Dermatol. Molecular mechanisms of tazarotene action in psoriasis.

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Keywords: Tazarotene, Tazorac; Zorac; AGN 190168 supplier, RAR/RXR, inhibitors, activators


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