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Tazarotene

Cat. No. M3973
Tazarotene Structure
Synonym:

Tazorac,Zorac

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL In DMSO USD 70 In stock
10mg USD 55 In stock
50mg USD 180 In stock
100mg USD 275 In stock
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Quality Control
Biological Activity

Tazarotene is a member of the acetylenic class of retinoids which binds at retinoid acid receptors (RAR) -β and -γ.Tazarotene is a retinoic acid receptor-specific retinoid with demonstrated efficacy in the topical treatment of psoriasis.Tazarotene exerts anti-inflammatory and immune-modulating activities toward both infective agents and damaged keratinocytes.Tazarotene down-regulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation.It is also up-regulates three novel genes TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which may mediate an antiproliferative effect.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 351.46
Formula C21H21NO2S
CAS Number 118292-40-3
Purity >99%
Solubility DMSO >10 mg/mL
Storage at -20°C
References

Tazarotene as alternative topical treatment for onychomycosis.
Campione E, et al. Drug Des Devel Ther. 2015 Feb 16;9:879-86. PMID: 25733808.

Tazarotene induces apoptosis in human basal cell carcinoma via activation of caspase-8/t-Bid and the reactive oxygen species-dependent mitochondrial pathway.
Wu CS, et al. DNA Cell Biol. 2014 Oct;33(10):652-66. PMID: 24927175.

Molecular mechanisms of tazarotene action in psoriasis.
Duvic M, et al. J Am Acad Dermatol. 1997 Aug;37(2 Pt 3):S18-24. PMID: 9270552.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tazarotene, Tazorac,Zorac supplier, RAR/RXR, inhibitors

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