All AbMole products are for research use only, cannot be used for human consumption.
Tazarotene is a member of the acetylenic class of retinoids which binds at retinoid acid receptors (RAR) -β and -γ. Tazarotene is a retinoic acid receptor-specific retinoid with demonstrated efficacy in the topical treatment of psoriasis. Tazarotene exerts anti-inflammatory and immune-modulating activities toward both infective agents and damaged keratinocytes. Tazarotene down-regulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation. It is also up-regulates three novel genes TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which may mediate an antiproliferative effect.
| Molecular Weight | 351.46 |
| Formula | C21H21NO2S |
| CAS Number | 118292-40-3 |
| Solubility (25°C) | DMSO >30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Duvic M, et al. J Am Acad Dermatol. Molecular mechanisms of tazarotene action in psoriasis.
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