| Cat.No. | Name | Information |
|---|---|---|
| M19285 | Vitamin A | Vitamin A (Retinol) is a naturally occuring fat-soluble vitamin that is important for normal vision, the immune system, and reproduction. It also plays roles in normal functioning of heart, lungs, kidneys, and other organs. |
| M2241 | Adapalene | Adapalene is a third-generation topical retinoid, it is a potent RAR agonist, with AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene is also an MST1 agonist. |
| M55691 | BMS641 | BMS641 (BMS-209641) is a selective RARβ agonist. BMS641 has a higher affinity for RARβ (Kd=2.5 nM) that is 100 times higher than that for RARα (Kd=225 nM) or RARγ (Kd=223 nM). |
| M55417 | Vitamin A-d6 | Vitamin A-d6 |
| M45398 | MSU-42011 | MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist that potently inhibits the expression of iNOS as well as p-ERK protein levels. In addition, MSU-42011 has immunomodulatory and antitumor activities for cancer research. |
| M30833 | Trifarotene | Trifarotene (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) shows ∼65-fold and ∼16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM), respectively. |
| M21365 | 9-cis-Retinoic Acid | 9-cis-Retinoic acid (ALRT1057), a derivative of vitamin A, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates the cell cycle and has anticancer, anti-inflammatory and neuroprotective activities. |
| M14528 | Palovarotene | Palovarotene is a first-in-class, selective, orally bioavailable retinoic acid receptor gamma (RAR-γ) agonist for use in studies related to muscular osteogenesis imperfecta (FOP). |
| M14527 | Magnolol | Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively. |
| M14526 | Ch55 | Ch55 is a potent synthetic retinoid. |
| M14525 | CD3254 | CD3254 is a potent and selective retinoid X receptor-like (RXR) agonist and significantly promotes reprogramming. |
| M13397 | Peretinoin | Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with EC50 of 9 μM. |
| M13345 | LE135 | LE135 is an effective RAR antagonist, which can selectively bind RARα (Ki is 1.4 μM) and RARβ (Ki is 220 nM), and has a higher affinity for RARβ. The LE135 is highly selective for RARγ, RXRα, RXRβ and RXRγ. LE135 is also a vitamin A acid receptor antagonist. |
| M10725 | LY2955303 | LY2955303 is an effective and selective antagonist of the retinoic acid receptor γ (RARγ). Ki The value is 1.09 nM. |
| M10507 | WYC-209 | WYC-209 is a novel inhibitor of tumor-repopulating cells (trcs), inducing trc apoptosis primarily via the caspase 3 pathway. |
| M9104 | HX 531 | HX 531 is a potent antagonist of retinoid X receptors (IC50 = 18 nM). |
| M8764 | MM11253 | MM11253 (SR11253) is a high-affinity RARγ-selective retinoid acid (RA) receptor antagonist (IC50 = 44 nM against ATRA for binding RARγ; IC50 =1 μM in case of RARα, RARβ, RXRα). |
| M8748 | UVI3003 | UVI3003 is a high-affinity selective Pan-retinoid X receptor (RXR) full antagonist. |
| M8199 | SR11237 | SR11237 is a retinoid X receptor (RXR) selective agonist without any RAR activity that leads to the formation of RXR/RXR homodimers and activation of reporter genes containing RXR response elements. In addition, SR11237 significantly promotes reprogramming. |
| M7719 | CD437 | CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis. |
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