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RAR/RXR Retinoic acid receptor/Retinoid X receptor

Cat.No.  Name Information
M19285 Vitamin A Vitamin A (Retinol) is a naturally occuring fat-soluble vitamin that is important for normal vision, the immune system, and reproduction. It also plays roles in normal functioning of heart, lungs, kidneys, and other organs.
M2241 Adapalene Adapalene is a third-generation topical retinoid, it is a potent RAR agonist, with AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner.
M21365 9-cis-Retinoic Acid 9-cis-Retinoic acid (ALRT1057), a derivative of vitamin A, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates the cell cycle and has anticancer, anti-inflammatory and neuroprotective activities.
M14528 Palovarotene Palovarotene is a selective, orally bioavailable retinoic acid receptor gamma (RAR-γ) agonist that may be used in studies related to muscular osteogenesis imperfecta (FOP).
M14527 Magnolol Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.
M14525 CD3254 CD3254 a potent and selective retinoid-X-receptor (RXR) agonist.
M13397 Peretinoin Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with EC50 of 9 μM.
M13345 LE135 LE135 is an effective RAR antagonist, which can selectively bind RARα (Ki is 1.4 μM) and RARβ (Ki is 220 nM), and has a higher affinity for RARβ. The LE135 is highly selective for RARγ, RXRα, RXRβ and RXRγ. LE135 is also a vitamin A acid receptor antagonist.
M10725 LY2955303 LY2955303 is an effective and selective antagonist of the retinoic acid receptor γ (RARγ). Ki The value is 1.09 nM.
M10507 WYC-209 WYC-209 is a novel inhibitor of tumor-repopulating cells (trcs), inducing trc apoptosis primarily via the caspase 3 pathway.
M9104 HX 531 HX 531 is a potent antagonist of retinoid X receptors (IC50 = 18 nM).
M8764 MM11253 MM11253 (SR11253) is a high-affinity RARγ-selective retinoid acid (RA) receptor antagonist (IC50 = 44 nM against ATRA for binding RARγ; IC50 =1 μM in case of RARα, RARβ, RXRα).
M8748 UVI3003 UVI3003 is a high-affinity selective Pan-retinoid X receptor (RXR) full antagonist.
M8199 SR11237 SR11237 and other ligands of retinoid X receptor (RXR) activate various nuclear receptors during development process.
M7719 CD437 CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.
M7568 AM580 AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM, respectively.
M7097 PA 452 PA 452 is a rXR antagonist.
M6573 CD 2665 CD 2665 is a selective RARβ/γ antagonist.
M6521 BMS 753 BMS 753 is a rARα-selective agonist.
M6416 AGN 193109 AGN 193109 is a high affinity pan-RAR antagonist.

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