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Palovarotene

Cat. No. M14528

All AbMole products are for research use only, cannot be used for human consumption.

Palovarotene Structure
Synonym:

R 667; Ro 3300074

Size Price Availability Quantity
1mg USD 60  USD60 In stock
5mg USD 130  USD130 In stock
10mg USD 205  USD205 In stock
25mg USD 410  USD410 In stock
50mg USD 700  USD700 In stock
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Quality Control & Documentation
Biological Activity

Palovarotene is a first-in-class, selective, orally bioavailable retinoic acid receptor gamma (RAR-γ) agonist for use in studies related to muscular osteogenesis imperfecta (FOP).

Chemical Information
Molecular Weight 414.54
CAS Number 410528-02-8
Solubility (25°C) DMSO 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Sheridan M Hoy. Palovarotene: First Approval

[2] Kelly L Wentworth, et al. Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva

[3] John B Lees-Shepard, et al. Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

[4] Benjamin M Wheatley, et al. Palovarotene inhibits connective tissue progenitor cell proliferation in a rat model of combat-related heterotopic ossification

[5] Matthew Hind, et al. Palovarotene, a novel retinoic acid receptor gamma agonist for the treatment of emphysema

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Keywords: Palovarotene, R 667; Ro 3300074 supplier, RAR/RXR, inhibitors, activators

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