Free shipping on all orders over $ 500

Fenretinide

Cat. No. M3150
Fenretinide Structure
Synonym:

4-HPR

Size Price Availability Quantity
10mM*1mL in DMSO USD 58  USD58 In stock
10mg USD 53  USD53 In stock
50mg USD 96  USD96 In stock
100mg USD 140  USD140 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Fenretinide (4-HPR) is a synthetic retinoid deriverative. Fenretinide is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death. Retinoids are substances related to vitamin A. Fenretinide has been investigated for potential use in the treatment of cancer, as well as in the treatment of cystic fibrosis, rheumatoid arthritis, acne, psoriasis, and has been found to also slow the production and accumulation of a toxin that leads to vision loss in Stargardt's patients.

Chemical Information
Molecular Weight 391.55
Formula C26H33NO2
CAS Number 65646-68-6
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Monish Ram Makena, et al. Vorinostat and fenretinide synergize in preclinical models of T-cell lymphoid malignancies

[2] Isabella Orienti, et al. Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19

[3] N Hail Jr, et al. Mechanisms of fenretinide-induced apoptosis

[4] Marco Corazzari, et al. Fenretinide: a p53-independent way to kill cancer cells

[5] E Ulukaya, et al. Fenretinide and its relation to cancer

Related RAR/RXR Products
MSU-42011

MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist that potently inhibits the expression of iNOS as well as p-ERK protein levels. In addition, MSU-42011 has immunomodulatory and antitumor activities for cancer research.

KCL-286

KCL-286 is an orally active retinoic acid receptor-beta (RAR-beta) agonist for studies related to spinal cord injury.

XS-060

XS-060 is a potent anticancer agent and RXRα antagonist.

BPA-B9

BPA-B9 is a RXRα ligand and antagonist targeting the pRXRα-PLK1 interaction.

ER 50891 quarterhydrate

ER 50891 quarterhydrate is a potent antagonist of retinoic acid receptor α(RARα).

  Catalog
Abmole Inhibitor Catalog




Keywords: Fenretinide, 4-HPR supplier, RAR/RXR, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.