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Adapalene

Cat. No. M2241
Adapalene Structure
Synonym:

Differin

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 90 In stock
200mg USD 120 In stock
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Quality Control
Biological Activity

Adapalene is a third-generation topical retinoid primarily used in the treatment of acne. Adapalene inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 412.52
Formula C28H28O3
CAS Number 106685-40-9
Purity >99%
Solubility DMSO 8 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Adapalene, Differin supplier, RAR/RXR, inhibitors

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