All AbMole products are for research use only, cannot be used for human consumption.
Adapalene is a third-generation topical retinoid, it is a potent RAR agonist, with AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene inhibits the viability of ES-2, HOV-7, MCF-7 , Hela, SW1990, HT1080, and MM-468 cells, with IC50s of 10.36 μM, 10.81 μM, 12.00 μM, 19.08 μM, 19.52 μM, 21.70 μM, and 31.47 μM, respectively Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro.
In vivo, Adapalene (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice.
Front Pharmacol. 2022 Feb 22;13:801624.
Adapalene Inhibits Prostate Cancer Cell Proliferation In Vitro and In Vivo by Inducing DNA Damage, S-phase Cell Cycle Arrest, and Apoptosis
Adapalene purchased from AbMole
| Molecular Weight | 412.52 |
| Formula | C28H28O3 |
| CAS Number | 106685-40-9 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Aura Rusu, et al. Recent Advances Regarding the Therapeutic Potential of Adapalene
[3] No authors listed. Adapalene
[5] Leila Tolaymat, et al. Adapalene
[6] S Jain. Topical tretinoin or adapalene in acne vulgaris: an overview
| Related RAR/RXR Products |
|---|
| YCT529
YCT529 is a potent, selective and orally active RAR-α inhibitor. |
| LG101506
LG101506 is a selective and orally active RXR modulator with a Ki of 2.7 nM for RXRα. |
| ER 50891
ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). |
| LG100754
LG100754 (UVI 2112) is a RXR dimers modulater. |
| AGN 196996
AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
