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HX 531

Cat. No. M9104
HX 531 Structure
Synonym:

HX531; HX-531

Size Price Availability Quantity
5mg USD 200 In stock
10mg USD 300 In stock
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Quality Control
Biological Activity

HX 531 is a potent antagonist of retinoid X receptors (IC50 = 18 nM). HX-531 promotes white and brown pre-adipocyte differentiation into white adipocytes. HX 531 also inhibits bexarotene-induced brown adipogenic reprogramming of myoblasts.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 483.56
Formula C29H29N3O4
CAS Number 188844-34-0
Purity 98.40%
Solubility DMSO 20 mM
Storage at -20°C
References

Brown Adipogenic Reprogramming Induced by a Small Molecule.
Nie B, et al. Cell Rep. 2017 Jan 17;18(3):624-635. PMID: 28099842.

Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid x receptor in human choriocarcinoma BeWo cells.
Suzuki K, et al. Biol Pharm Bull. 2009 Jul;32(7):1177-82. PMID: 19571381.

Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. II. Effects after intrathecal administration.
Alique M, et al. Br J Pharmacol. 2006 Sep;149(1):65-72. PMID: 16847438.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: HX 531, HX531; HX-531 supplier, RAR/RXR, inhibitors

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