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HX 531

Cat. No. M9104
HX 531 Structure
Synonym:

HX531; HX-531

Size Price Availability Quantity
1mg USD 48  USD48 In stock
5mg USD 85  USD85 In stock
10mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

HX 531 is a potent antagonist of retinoid X receptors (IC50 = 18 nM). HX-531 promotes white and brown pre-adipocyte differentiation into white adipocytes. HX 531 also inhibits bexarotene-induced brown adipogenic reprogramming of myoblasts.

Chemical Information
Molecular Weight 483.56
Formula C29H29N3O4
CAS Number 188844-34-0
Solubility (25°C) DMSO 20 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nie B, et al. Cell Rep. Brown Adipogenic Reprogramming Induced by a Small Molecule.

[2] Suzuki K, et al. Biol Pharm Bull. Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid x receptor in human choriocarcinoma BeWo cells.

[3] Alique M, et al. Br J Pharmacol. Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. II. Effects after intrathecal administration.

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