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9-cis-Retinoic Acid

Cat. No. M21365
9-cis-Retinoic Acid Structure


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5mg USD 430  USD430 In stock
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Quality Control & Documentation
Biological Activity

9-cis-Retinoic acid (ALRT1057), a derivative of vitamin A, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates the cell cycle and has anticancer, anti-inflammatory and neuroprotective activities.

Chemical Information
Molecular Weight 300.44
Formula C20H28O2
CAS Number 5300-03-8
Solubility (25°C) DMSO : 25 mg/mL
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Francesca Pecori Giraldi, et al. Sci Rep. Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues

[2] Hua Yang, et al. Anticancer Drugs. Effects of 9-cis-retinoic acid on the proliferation and apoptosis of cutaneous T-cell lymphoma cells

[3] Maureen A Kane. Biochim Biophys Acta. Analysis, occurrence, and function of 9-cis-retinoic acid

[4] Gene K Lee, et al. Lymphat Res Biol. Prolymphangiogenic Effects of 9- cis Retinoic Acid Are Enhanced at Sites of Lymphatic Injury and Dependent on Treatment Duration in Experimental Postsurgical Lymphedema

[5] Zhiqing Yuan, et al. Biochem Biophys Res Commun. 9-cis-retinoic acid elevates MRP3 expression by inhibiting sumoylation of RXRα to alleviate cholestatic liver injury

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Keywords: 9-cis-Retinoic Acid, ALRT1057 supplier, RAR/RXR, inhibitors, activators

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