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R-(+)-Pramipexole is a neuroprotective agent; weak non-ergoline dopamine agonist. R-(+)-Pramipexole has been found to have neuroprotective effects and is being investigated for treatment of ALS. It reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, R-(+)-Pramipexole has much lower dopamine agonist activity.
| Molecular Weight | 284.25 |
| Formula | C10H17N3S · 2HCl |
| CAS Number | 104632-27-1 |
| Solubility (25°C) | Water: ≥15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Lynn M Trotti, et al. Iron for the treatment of restless legs syndrome
[4] Angelo Antonini, et al. Pharmacokinetic evaluation of pramipexole
[5] D W Claussen. Mirapex: pramipexole dihydrochloride tablets
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