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Alvimopan dihydrate

Cat. No. M5403
Alvimopan dihydrate Structure
Synonym:

LY 246736 dihydrate; ADL 8-2698 dihydrate

Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 230  USD230 In stock
50mg USD 670  USD670 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Alvimopan dihydrate(LY 246736; ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 460.56
Formula C25H36N2O6
CAS Number 170098-38-1
Purity >98%
Solubility 10mM in DMSO
Storage at -20°C
References

[1] Earnshaw SR, et al. J Am Coll Surg. Economic Impact of Alvimopan Considering Varying Definitions of Postoperative Ileus.

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Keywords: Alvimopan dihydrate, LY 246736 dihydrate; ADL 8-2698 dihydrate supplier, Opioid Receptor, inhibitors

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