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Lanolin

Cat. No. M6238
Lanolin Structure
Synonym:

Wool fat

Size Price Availability Quantity
500mg USD 20  USD20 In stock
1g USD 25  USD25 In stock
5g USD 40  USD40 In stock
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Quality Control & Documentation
Biological Activity

Lanolin is a complex waxy substance composed of varying quantities of long-chain waxy esters and lanolin alcohols, acids and polycarbons, used as adjuvant. Lanolin has been used as a constituent of VALAP (Vaseline, lanolin, paraffin) to stabilize glass slides during worm-immobilization method. 

Soluble in ether, petroleum ether, chloroform and petroleum benzene. Insoluble in water.

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
CAS Number 8006-54-0
Solubility (25°C) Soluble in ether
Soluble in petroleum ether
Soluble in chloroform
Soluble in petroleum benzene
Storage 2-8°C, dry, sealed, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] J Freund, et al. Science. IMMUNIZATION AGAINST MALARIA: VACCINATION OF DUCKS WITH KILLED PARASITES INCORPORATED WITH ADJUVANTS

[2] C C OPRESCU. Stud Cercet Inframicrobiol. Allergic sensitization of guinea pigs to Escherichia coli in presence of chloroform-soluble lipids of Mycobacterium tuberculosis and of certain adjuvants (lanolin and paraffin oil)

[3] P C Klykken, et al. Curr Top Microbiol Immunol. The adjuvancy of silicones: dependency on compartmentalization

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