Lanolin is a complex waxy substance composed of varying quantities of long-chain waxy esters and lanolin alcohols, acids and polycarbons, used as adjuvant. Lanolin has been used as a constituent of VALAP (Vaseline, lanolin, paraffin) to stabilize glass slides during worm-immobilization method.
Soluble in ether, petroleum ether, chloroform and petroleum benzene. Insoluble in water.
Vopr Virusol. 2011 Apr ;56(2):41-6.
Evaluation of the efficiency and reactogenicity of emulsion-based adjuvant systems in the manufacture of polyclonal enteroviral diagnostic sera
Lanolin purchased from AbMole
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CAS Number | 8006-54-0 |
Solubility (25°C) | Soluble in ether Soluble in petroleum ether Soluble in chloroform Soluble in petroleum benzene |
Storage | 2-8°C, dry, sealed, protect from light |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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