Aluminum stearate is a saline form of stearic acid used as a thickener and emulsifier, and to regulate the stability and suspension of a cosmetic formulation, used as adjuvant.
Soluble in alkali, glycol, chlorinated hydrocarbons, petroleum, benzene, turpentine oil, mineral oil, vegetable oil, mixture of benzene, toluene and the three xylene isomers. Insoluble in water, ethanol and ether.
Zhongguo Zhong Yao Za Zhi. 2014 Jun;39(13):2489-94.
Preparation and pharmacokinetic evaluation of long-acting injectable oily suspensions for ophiopogonis radix polysaccharide MDG-1.
Aluminum stearate purchased from AbMole
| Molecular Weight | 877.39 |
| Formula | C54H105AlO6 |
| CAS Number | 637-12-7 |
| Solubility (25°C) | Soluble in alkali Soluble in glycol |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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