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Aluminum Phosphate

Cat. No. M40632
Aluminum Phosphate Structure
Size Price Availability Quantity
5g USD 40  USD40 In stock
10g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Aluminum Phosphate is a widely used adjuvant and has been shown to increase the excretion rate of strontium for use in studies related to vaccines and gastrointestinal diseases.

Chemical Information
Molecular Weight 121.95
Formula AlO4P
CAS Number 7784-30-7
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ting Zhang et al. Pharmaceutics. Research Progress of Aluminum Phosphate Adjuvants and Their Action Mechanisms

[2] Jean Noël Yankwa Djobo et al. RSC Adv. Preparation of acid aluminum phosphate solutions for metakaolin phosphate geopolymer binder

[3] Sietske Kooijman et al. J Pharm Sci. Aluminum Hydroxide And Aluminum Phosphate Adjuvants Elicit A Different Innate Immune Response

[4] Shiva Samsam Shariat et al. J Res Pharm Pract. Effectiveness of Plasmapheresis in Aluminum Phosphate Poisoning

[5] Peng He et al. Hum Vaccin Immunother. Advances in aluminum hydroxide-based adjuvant research and its mechanism

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