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Berberine chloride

Cat. No. M5000
Berberine chloride Structure
Synonym:

Natural Yellow 18 chloride

Size Price Availability Quantity
50mg USD 40  USD40 In stock
100mg USD 60  USD60 In stock
500mg USD 105  USD105 In stock
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Quality Control & Documentation
Biological Activity

Treatment with BBR(Berberine) in rats on the atherogenic diet reduced plasma total cholesterol and nonHDL cholesterol levels by 29%-33% and 31%-41%, respectively, with no significant differences being observed among the three doses.Berberine induced both apoptotic and autophagic death of HepG2 cells, which was associated with a significant activation of AMPK and an increased expression of the inactive form of acetyl-CoA carboxylase (ACC).

Chemical Information
Molecular Weight 371.81
Formula C20H18ClNO4
CAS Number 633-65-8
Solubility (25°C) DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wang Y,et.al. Metabolism. Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption.

[2] Yu R,et.al. Cancer Cell Int. Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation.

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