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Sulfadimethoxine

Cat. No. M1939
Sulfadimethoxine Structure
Synonym:

Sulphadimethoxine

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 44  USD44 In stock
100mg USD 56  USD56 In stock
200mg USD 74  USD74 In stock
500mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Sulfadimethoxine is a sulfonamide antibiotic. Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid. Sulfadimethoxine blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. The sorption coefficients (K(d)) obtained for the sulfonamides investigated were quite low (from 0.20 to 381.17 mL g(-1) for sulfadimethoxine and from 0.39 to 35.09 mL g(-1) for sulfaguanidine), which indicated that these substances are highly mobile and have the potential to run off into surface waters and/or infiltrate ground water.

Chemical Information
Molecular Weight 310.33
Formula C12H14N4O4S
CAS Number 122-11-2
Solubility (25°C) DMSO ≥ 56 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Białk-Bielińska A, et al. Chemosphere. Sulfadimethoxine and sulfaguanidine: their sorption potential on natural soils.

[2] Migliore L, et al. Dose Response. Phytotoxic antibiotic sulfadimethoxine elicits a complex hormetic response in the weed lythrum salicaria L.

[3] Kemmochi S, et al. J Cancer Res Clin Oncol. Involvement of PTEN/Akt signaling in capsular invasive carcinomas developed in a rat two-stage thyroid carcinogenesis model after promotion with sulfadimethoxine.

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Keywords: Sulfadimethoxine, Sulphadimethoxine supplier, Antibiotic, inhibitors, activators


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