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Teicoplanin

Cat. No. M2009
Teicoplanin Structure
Synonym:

Targocid, Teichomycin

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 66  USD66 In stock
100mg USD 102  USD102 In stock
500mg USD 328  USD328 In stock
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Quality Control & Documentation
Biological Activity

Teicoplanin is a long-acting glycopeptide antibiotic derived from actinomycetes that inhibits cell wall synthesis and interferes with the process of synthesizing new portions of peptidoglycan, and has a good inhibitory effect on gram-positive pathogens (including staphylococcal biofilms).

Chemical Information
Molecular Weight 1709.39
Formula C77H77N9O31Cl2·R
CAS Number 61036-62-2
Solubility (25°C) Water 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Li TL, et al. Chem Biol. Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.

[2] Sosio M, et al. Microbiology. Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.

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Keywords: Teicoplanin, Targocid, Teichomycin supplier, Antibiotic, inhibitors, activators


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