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Marbofloxacin is a quinolone, and acts by inhibiting bacterial DNA replication. It is effective against enterobacteria, Pasteurella, Pseudomonas and staphylococci. Marbofloxacin has demonstrated considerable pharmokinetic variation among avian species. Marbofloxacin significantly kills Leishmania promastigotes and intracellular amastigotes in a dose-dependent manner, more efficient than meglumine antimoniate and sodium stibogluconate. Clearance and V(d(ss)) for marbofloxacin was 4.62 +/- 0.67 mL/min/kg and 1.6 +/- 0.25 L/kg. Variance of the AUC(0-inf) of marbofloxacin was low, with a CV = 15% and a CV = 31% after oral administration.
| Molecular Weight | 362.36 |
| Formula | C17H19FN4O4 |
| CAS Number | 115550-35-1 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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