About 30 results found for searched term "PT 1" (0.014 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1771 | Ataluren | CFTR |
| PTC124 | ||
| Ataluren (PTC124) is a novel, orally available small molecular CFTR-G542X nonsense allele inhibitor. | ||
| M1871 | Roflumilast | PDE |
| APTA-2217; BYK 20869; B9302-107 | ||
| Roflumilast (APTA-2217; BYK 20869; B9302-107) is a novel and selective, long-acting inhibitor of phosphodiesterase 4 (PDE-4). | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2089 | Irinotecan Hydrochloride Trihydrate | Topoisomerase |
| Campto, CPT-11 | ||
| Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I. | ||
| M2228 | Methotrexate | Antifolate |
| Amethopterin; CL14377; WR19039 | ||
| Methotrexate (Amethopterin) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. | ||
| M2403 | MDK83190 | Caspase |
| Apoptosis Activator 2; MDK-83190 | ||
| MDK83190 (Apoptosis Activator 2) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. | ||
| M2701 | Fidaxomicin | Antibiotic |
| OPT-80; PAR-101; Clostomicin B1; Tiacumicin B | ||
| Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit. | ||
| M3002 | Scriptaid | HDAC |
| Scriptide; GCK1026 | ||
| Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3. | ||
| M3274 | Pentagastrin | Cholecystokinin Receptor |
| Peptavlon; ICI-50123 | ||
| Pentagastrin (ICI-50123) is a synthetic polypeptide that has effects like gastrin when given parenterally. | ||
| M25394 | BPTF-IN-1 | Epigenetic Reader Domain |
| compound AU1 | ||
| BPTF-IN-1 (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a Kd of 2.8 μM. BPTF-IN-1 shows to be selective for BPTF over BRD4 bromodomain. | ||
| M3881 | Tafluprost | Prostaglandin Receptor |
| Taflotan, Zioptan, AFP-168, MK2452 | ||
| Tafluprost is a fluorinated analog of prostaglandin F2-alpha and a PGF2alpha agonist that may be used in glaucoma-related studies. | ||
| M1555 | Amyloid β-Peptide (1-42) human,TFA | Amyloid |
| Aβ1-42; β-Amyloid (1-42) | ||
| Amyloid β-Peptide (1-42) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. | ||
| M1333 | Talabostat mesylate | Dipeptidyl Peptidase |
| BXCL701 mesylate; Val-boroPro mesylate; PT100 mesylate | ||
| Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM). | ||
| M4465 | Irinotecan | Topoisomerase |
| (+)-Irinotecan; CPT-11; VAL-413 | ||
| Irinotecan is an inhibitor of Topoisomerase I, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC50s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively. | ||
| M4972 | 3-Amino-5-mercapto-1,2,4-triazole | Plant growth regulators |
| Amitrole (3-amino-1,2,4-triazole) is a widely used herbicide. | ||
| M5102 | PTP1B-IN-2 | Phosphatase |
| PTP1B-IN-2 is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM. | ||
| M58149 | Recombinant Vaccinia virus B18R (HEK293, C-6His) | Cytokines and Growth Factors |
| Soluble interferon alpha/beta receptor B18; VACWR200 | ||
| B18R is a type I interferon (IFN)-binding protein encoded by the B18R open reading frame in the Western Reserve strain of vaccinia virus. B18R has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. Secreted B18R binds to uninfected and infected cells. B18R presents at the cell surface and protects cells from the antiviral state. | ||
| M5360 | 2-Aminoheptane | Others |
| Tuaminoheptanez, Tuamine, Heptamine, 1-Methylhexylamine, 2-Heptylamine | ||
| 2-Aminoheptane is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor. | ||
| M5711 | Irinotecan hydrochloride | Topoisomerase |
| CPT-11 HCl | ||
| Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. | ||
| M6579 | Cerestat | Others |
| Aptiganel; CNS-1102 | ||
| Cerestat (also known as Aptiganel, CNS-1102) is a potent and noncompetitive NMDA receptor antagonist. | ||
| M6826 | INCA-6 | NFAT |
| INCA6; Triptycene-1,4-quinone | ||
| INCA-6 is a inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT). | ||
| M7173 | PT 1 | Others |
| PT 1 is a aMPK activator. | ||
| M9049 | MPTP HCl | Dopamine Receptor |
| MPTP hydrochloride; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride | ||
| MPTP is dehydrogenated in nigrostriatal cells to generate MPP+, which in turn inhibits mitochondrial complex enzymes and contributes to cell death. It can be used to construct animal models of Parkinson's disease. | ||
| M9130 | LSN3154567 | NAMPT |
| Nampt-IN-1 | ||
| LSN3154567 (also known as Nampt-IN-1) is a potent and elective NAMPT inhibitor, inhibits purified NAMPT with an IC50 of 3.1 nM. | ||
| M9427 | CU-CPT17e | TLR |
| CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist, which activates TLR3, TLR8 and TLR9. | ||
| M9567 | Leptin (116-130) mouse | Others |
| LEP(116-130) mouse | ||
| Leptin (116-130) mouse is a synthetic leptin peptide fragment. | ||
| M9570 | PTP1B-IN-9 | Proteasome |
| PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor with anticancer activity. | ||
| M9771 | TRAP-6 | Peptides |
| Thrombin Receptor Activator Peptide 6; PAR-1 agonist peptide | ||
| TRAP-6 (Thrombin Receptor Activator Peptide 6) is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. | ||
| M10059 | Prolactin-Releasing Peptide (1-31) (human) | Peptides |
| Prolactin-Releasing Peptide (1-31) (human) is a high affinity GPR10 ligand. | ||
| M10063 | Bremelanotide Acetate | Melanocortin Receptor |
| PT-141 Acetate | ||
| Bremelanotide Acetate (PT-141 Acetate) is a peptide containing seven amino acids and is also a macrocyclic compound. In addition, Bremelanotide Acetate is an agonist of the melanocortin 4 receptor (MC4R). | ||
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