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Amyloid β-Peptide (1-42) human,TFA

Cat. No. M1555
Amyloid β-Peptide (1-42) human,TFA Structure
Synonym:

Aβ1-42; β-Amyloid (1-42)

Size Price Availability Quantity
1mg USD 215  USD215 In stock
5mg USD 660  USD660 In stock
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Biological Activity

Amyloid β-Peptide (1-42) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

Chemical Information
Molecular Weight 4514.04
Formula C203H311N55O60S
CAS Number 107761-42-2
Solubility (25°C) DMSO 30 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Olayemi Joseph Olajide, et al. Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex

[2] Eun-Jeong Yang, et al. Phloroglucinol attenuates oligomeric amyloid beta peptide 1-42-induced astrocytic activation by reducing oxidative stress

[3] Marcia A LeVatte, et al. Preparation and characterization of a highly soluble Aβ 1-42 peptide variant

[4] D Allan Butterfield, et al. Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease

[5] Roberta Facchinetti, et al. An Animal Model of Alzheimer Disease Based on the Intrahippocampal Injection of Amyloid β-Peptide (1-42)

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Keywords: Amyloid β-Peptide (1-42) human,TFA, Aβ1-42; β-Amyloid (1-42) supplier, Amyloid, inhibitors, activators

 
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