Amyloid β-Peptide (1-42) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
|Solubility (25°C)||DMSO 30 mg/mL|
|Storage||-20°C, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Amyloid Products|
PMN310 is a beta-amyloid oligomer (AβO) antibody that can be used in studies related to Alzheimer's disease (AD).
Lanuginosine is an AChE inhibitor (IC50: 10.9 μM).
BIBD-124 binds amyloid beta (Aβ) plaque with an IC50 value of 9.51 nM.
Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells.
QR-0217 is a potent Aβ1-40 aggregation inhibitor with an IC50 value of 7.5 µM.
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