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Ginsenoside Rg1 is part of a class of triterpene saponins and steroid glycosides. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. It is found exclusively in the plant genus Panax, or ginseng. Ginsenoside Rg1 suppresses renal cell apoptotic and fibrotic process partly through inhibition of ERS- and UPR-related apoptotic pathway in the kidneys after UUO. Ginsenoside Rg1 may ameliorate isoflurane-induced caspase-3 activation by inhibiting mitochondrial dysfunction. G-Rg1 mitigates the progression of chronic CsA nephropathy, at least in part, through inhibition of ER stress-triggered tubular cell apoptosis. Ginsenoside Rg1 inhibits the shear induced inflammation by suppressing the MAPK pathway. Ginsenoside Rg1 also reduces NF-κB nuclear translocation. Rg1 may serve as a novel anti-inflammatory agent for inflammation-induced cardiovascular diseases treatment.
| Molecular Weight | 801.01 |
| Formula | C42H72O14 |
| CAS Number | 22427-39-0 |
| Solubility (25°C) | DMSO 60 mg/mL Water 10 mg/mL (Need ultrasonic) |
| Storage | -20°C, protect from light, sealed |
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