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Amyloid Amyloid

Cat.No.  Name Information
M50214 AC 187 TFA AC 187 TFA is a potent, orally active and neuroprotective amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 TFA is more selective for amylin receptors than calcitonin and CGRP receptors.
M28783 DC-Chol hydrochloride DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner.
M24594 Lecanemab Lecanemab (BAN-2401) is an IgG1 anti-soluble aggregated amyloid beta (Aβ) monoclonal antibody. Lecanemab shows activity across oligomers, protofibrils and insoluble fibrils. Lecanemab can be used for the research of Alzheimer's Disease.
M21812 ALZ-801 ALZ-801 is an orally active small molecule compound that is also an inhibitor of β-amyloid A4 (APP) and a precursor compound of homotaurine, which inhibits the formation of neurotoxic amyloid oligomers, and may be used in studies related to Alzheimer's disease (AD).
M14554 Leucomethylene blue mesylate Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease.
M14552 Hematoxylin Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from the logwood tree, Haematoxylon campechianum.
M10194 Amyloid β Protein 1-40 (TFA) β-Amyloid (1-40) TFA is a major protein fragment found in brain plaques of Alzheimer's disease.
M9470 Aftin-4 Aftin-4 is an inducer of Aß-42 peptide production.
M9071 Amyloid beta-peptide(25-35) Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells.
M8968 FPS-ZM1 FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to RAGE with a Ki of 25 nM.
M8560 Anle138b Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′s disease in animal models.
M6952 Methoxy-X04 Methoxy-X04 is a fluorescent amyloid β detector; brain penetrant.
M5618 Eprodisate disodium Eprodisate Disodium is the orally available disodium salt form of Eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis.
M5169 Bavachinin Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae;has potent anti-angiogenic activity.
M4443 Spinosin Spinosyn is a neuroprotective C-glycoside flavonoid isolated from the seeds of Zizyphus jujube. Spinosyn inhibits the production and polymerization of Aβ1-42 by activating the Nrf2/HO-1 pathway.
M4360 Qingyangshengenin-B Qingyangshengenin B C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against the toxicity of Aβ by decreasing the expression of Aβ at mRNA level. Qingyangshengenin B has antiepileptic activity.
M4101 Notoginsenoside-R1 Notoginsenoside R1 (Sanchinoside R1) is a saponin isolated from P. notoginseng. Notoginsenoside R1 has antioxidant, anti-inflammatory, anti-angiogenic and anti-apoptotic activities. Notoginsenoside R1 provides cardiac protection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 may also provide neuroprotection.
M4096 Saikosaponin-C Saikosaponin C, the active ingredient in Bupleurum, mainly targets amyloid beta and tau proteins in ALZHEIMER's disease. Saikosaponin C inhibited the release of Aβ1-40 and Aβ1-42, and inhibited abnormal tau phosphorylation, but had no effect on BACE1 activity and expression.
M4074 Ginsenoside-Re Ginsenoside Re (Ginsenoside B2) is a ginseng - ginseng extract. Ginsenoside Re reduces beta-amyloid (Aβ). Ginsenoside Re also exerts anti-inflammatory effects by inhibiting JNK and NF-κB.
M3940 Ginsenoside Rg1 Ginsenoside Rg1 is part of a class of triterpene saponins and steroid glycosides. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. It is found exclusively in the plant genus Panax, or ginseng.




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