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Amyloid Amyloid

Cat.No.  Name Information
M54775 Methyl tridecanoate Methyl tridecanoate inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE).
M54716 Trontinemab Trontinemab is a bispecific human IgG1-κ antibody that targets amyloid β A4 precursor protein (APP) and transferrin receptor (TFRC).Trontinemab may be used in Alzheimer's disease-related studies.
M50214 AC 187 TFA AC 187 TFA is a potent, orally active and neuroprotective amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 TFA is more selective for amylin receptors than calcitonin and CGRP receptors.
M28783 DC-Chol hydrochloride DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner.
M24855 Donanemab Donanemab (LY3002813) is a humanized IgG1κ monoclonal antibody directed at an N‐terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research.
M24639 Aducanumab Aducanumab (BIIB037), a human monoclonal antibody selective for aggregated forms of amyloid beta (Aβ). Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research.
M21812 ALZ-801 ALZ-801 is an orally active small molecule compound that is also an inhibitor of β-amyloid A4 (APP) and a precursor compound of homotaurine, which inhibits the formation of neurotoxic amyloid oligomers, and may be used in studies related to Alzheimer's disease (AD).
M14555 Rutin hydrate Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities.
M14554 Leucomethylene blue mesylate Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease.
M10194 Amyloid β Protein 1-40 (TFA) β-Amyloid (1-40) TFA is a major protein fragment found in brain plaques of Alzheimer's disease.
M9470 Aftin-4 Aftin-4 is an inducer of Aß-42 peptide production.
M9071 Amyloid beta-peptide(25-35) Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells.
M8968 FPS-ZM1 FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to RAGE with a Ki of 25 nM.
M8560 Anle138b Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′s disease in animal models.
M6952 Methoxy-X04 Methoxy-X04 is a fluorescent amyloid β detector; brain penetrant.
M5618 Eprodisate disodium Eprodisate Disodium is the orally available disodium salt form of Eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis.
M5169 Bavachinin Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae;has potent anti-angiogenic activity.
M4443 Spinosin Spinosyn is a neuroprotective C-glycoside flavonoid isolated from the seeds of Zizyphus jujube. Spinosyn inhibits the production and polymerization of Aβ1-42 by activating the Nrf2/HO-1 pathway.
M4360 Qingyangshengenin-B Qingyangshengenin B C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against the toxicity of Aβ by decreasing the expression of Aβ at mRNA level. Qingyangshengenin B has antiepileptic activity.
M4216 Timosaponin BII Timosaponin BII is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities.

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