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Rutin hydrate

Cat. No. M14555
Rutin hydrate Structure
Synonym:

Rutoside hydrate; Quercetin 3-O-rutinoside hydrate

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500mg USD 45  USD45 In stock
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Biological Activity

Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress.

Chemical Information
Molecular Weight 740.26
CAS Number 207671-50-9
Solubility (25°C) DMSO 50 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tarek Hasan, et al. Rutin hydrate and extract from Castanopsis tribuloides reduces pyrexia via inhibiting microsomal prostaglandin E synthase-1

[2] Idaresit Ekaette, et al. Ultrasound processing of rutin in food-grade solvents: Derivative compounds, antioxidant activities and optical rotation

[3] Dalia G Mostafa, et al. Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress

[4] Letcia Costa Tomazelli, et al. SPF enhancement provided by rutin in a multifunctional sunscreen

[5] Ghada A Abdel-Aleem, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling

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Keywords: Rutin hydrate, Rutoside hydrate; Quercetin 3-O-rutinoside hydrate supplier, Amyloid, inhibitors, activators

 
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