Free shipping on all orders over $ 500

Ginsenoside-Re

Cat. No. M4074
Ginsenoside-Re Structure
Synonym:

Ginsenoside B2; Panaxoside Re; Chikusetsusaponin IVc; Sanchinoside Re

Size Price Availability Quantity
20mg USD 100  USD100 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Ginsenoside Re (Ginsenoside B2) is a ginseng - ginseng extract. Ginsenoside Re reduces beta-amyloid (Aβ). Ginsenoside Re also exerts anti-inflammatory effects by inhibiting JNK and NF-κB.

Chemical Information
Molecular Weight 947.14
Formula C48H82O18
CAS Number 52286-59-6
Form Solid
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Iskander Madhi, et al. Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF‑κB signaling in microglia

[2] Huiyuan Sun, et al. Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination

[3] Weijie Xie, et al. Ginsenoside Re Attenuates High Glucose-Induced RF/6A Injury via Regulating PI3K/AKT Inhibited HIF-1α/VEGF Signaling Pathway

[4] Gyeong Hee Lee, et al. Ginsenoside Re Mitigates 6-Hydroxydopamine-Induced Oxidative Stress through Upregulation of GPX4

[5] Lu Peng, et al. Ginsenoside Re: pharmacological effects on cardiovascular system

Related Amyloid Products
Methyl tridecanoate

Methyl tridecanoate inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE).

Trontinemab

Trontinemab is a bispecific human IgG1-κ antibody that targets amyloid β A4 precursor protein (APP) and transferrin receptor (TFRC).Trontinemab may be used in Alzheimer's disease-related studies.

RAGE antagonist peptide

RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist.

Fmoc-Ala-Glu-Asn-Lys-NH2

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage.

β-Amyloid peptide(16-20)

β-Amyloid peptide(16-20) is a amino acid sequences (KLVFF) of Amyloid-β (Abeta).

  Catalog
Abmole Inhibitor Catalog




Keywords: Ginsenoside-Re, Ginsenoside B2; Panaxoside Re; Chikusetsusaponin IVc; Sanchinoside Re supplier, Amyloid, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.