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Aftin-4

Cat. No. M9470

All AbMole products are for research use only, cannot be used for human consumption.

Aftin-4 Structure
Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

Aftin-4 is an inducer of Aß-42 peptide production. Aftin-4 potently and selectively increases Aβ1-42 in N2a cells, primary neurons, and brain lysates, with an EC50 value around 30 μM.

Chemical Information
Molecular Weight 368.48
Formula C20H28N6O
CAS Number 866893-90-5
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Meunier J, et al. J Alzheimers Dis. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative.

[2] Bettayeb K, et al. FASEB J. Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action.

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Keywords: Aftin-4 supplier, Amyloid, inhibitors, activators

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